Sushil Baral, Nepal
Bir hospital,NAMS Internal MedicinePresenter of 1 Presentation
ASSESSMENT OF LIPID ABNORMALITIES AND CARDIOVASCULAR RISK INDICES IN TYPE 2DIABETES MELLITUS
Abstract
Background and Aims
NTRODUCTION
Incidence of cardiovascular events is increased more among diabetic patients. Dyslipidemia in diabetes is characterized by elevated triglyceride (TG), low (HDL-C) and increased prevalence of small dense low density lipoprotein cholesterol (LDL-C) particles. Serum total cholesterol (TC) and LDL-C have been used as major laboratory measures in clinical practice to assess cardiovascular risk. Recent studies,have shown that Non HDLc is like or better than LDL-C alone in the prediction of cardoivascular risk. the aim of this study is to assess the lipid abnormalities with cardiovascular risk using atherogenic coefficient,Cardiac Risk Ratio (TC/HDLc and LDLc/HDLc), TG/HDLc and Non- HDL
Methods
A cross-sectional descriptive study conducted at Bir hospital (tertiary care center) Nepal. Patients diagnosed as diabetes with age 30 years or above were selected in this study during a period of 1 yr.
Results
The mean age of the patients enrolled was 55.08±1.11 (34-81) year with male (52 %) to female (48%) ratio is 1.08:1. In this study the mean Non HDLc was 165.24±43.40 mg/dl (65-323).This study show the strong correlation of Non HDLc with total cholesterol(r=.990,p=0.000),LDLc(r=.602,p=0.000),TG(r=.411,p=0.000),LDLc/HDLc(r=.580,p=0.000),TC/HDLc((r=.866,p=0.000),TG/HDLc(r=.390 ,p=0.000). The mean AC in our study was 4.0±1.09. The finding was slightly higher is female compare to male i.e mean ±S.D 4.07±1.31 and 3.94±1.15.
Conclusions
The association between abnormal lipid levels and cardiovascular risk is evident among patients with diabetes mellitus. In this study there is the correlation with FBS, Non HDL-c cholesterol, Cardio risk ratio, TG/HDLc, Atherogenic coefficient. Hence Non-HDL cholesterol and Atherogenic indices proves to be more sensitive and a better predictor of cardiovascular events.