NTRODUCTION
Incidence of cardiovascular events is increased more among diabetic patients. Dyslipidemia in diabetes is characterized by elevated triglyceride (TG), low (HDL-C) and increased prevalence of small dense low density lipoprotein cholesterol (LDL-C) particles. Serum total cholesterol (TC) and LDL-C have been used as major laboratory measures in clinical practice to assess cardiovascular risk. Recent studies,have shown that Non HDLc is like or better than LDL-C alone in the prediction of cardoivascular risk. the aim of this study is to assess the lipid abnormalities with cardiovascular risk using atherogenic coefficient,Cardiac Risk Ratio (TC/HDLc and LDLc/HDLc), TG/HDLc and Non- HDL
A cross-sectional descriptive study conducted at Bir hospital (tertiary care center) Nepal. Patients diagnosed as diabetes with age 30 years or above were selected in this study during a period of 1 yr.
The mean age of the patients enrolled was 55.08±1.11 (34-81) year with male (52 %) to female (48%) ratio is 1.08:1. In this study the mean Non HDLc was 165.24±43.40 mg/dl (65-323).This study show the strong correlation of Non HDLc with total cholesterol(r=.990,p=0.000),LDLc(r=.602,p=0.000),TG(r=.411,p=0.000),LDLc/HDLc(r=.580,p=0.000),TC/HDLc((r=.866,p=0.000),TG/HDLc(r=.390 ,p=0.000). The mean AC in our study was 4.0±1.09. The finding was slightly higher is female compare to male i.e mean ±S.D 4.07±1.31 and 3.94±1.15.
The association between abnormal lipid levels and cardiovascular risk is evident among patients with diabetes mellitus. In this study there is the correlation with FBS, Non HDL-c cholesterol, Cardio risk ratio, TG/HDLc, Atherogenic coefficient. Hence Non-HDL cholesterol and Atherogenic indices proves to be more sensitive and a better predictor of cardiovascular events.