Self-care is how individuals protect their own health, prevent disease, and treat illness, both with and without the support of a healthcare provider. Interventions such as condoms, HIV self-testing, PrEP, self-sampling for STIs, and digital solutions have led to a greater configuration of self-led HIV prevention, treatment and care possibilities than ever before. COVID-19 has accelerated and emphasized the need for self-care interventions to meet the needs of people who live with or are at risk of HIV to alleviate an already overburdened healthcare system. The accessibility of self-care is dependent on the support of governments and policymakers to ensure there is deliberate integration of self-care into health policy, program, and practice. Through this panel discussion, the speakers will explain how self-care has been an integral component of the healthcare system and integrated in HIV response, reshaping how HIV prevention, treatment and care services are provided.