Over the past 4 decades, innovations in HIV prevention and treatment have helped shift the course of the HIV epidemic from a disease of high morbidity and mortality to one that is chronic and manageable for most. However, there are still gaps in care that must be overcome to adequately address the challenges faced by people living with and at risk of HIV. Jeffrey S. Crowley, MPH, Program Director of Infectious Disease Initiatives at the O’Neill Institute for National and Global Health Law at Georgetown University, and Christian Ramers, MD, MPH, AAHIVM, Assistant Medical Director for Research & Special Populations and Director of Graduate Medical Education at Family Health Centers of San Diego, discuss how innovations have driven changes in HIV care, and how telehealth might just be the next disruptive innovation in HIV management.