Since 2005, China has carried out Major Science and Technology Projects on AIDS and other infectious diseases, and has made great progress on prevention and intervention for key populations. Moreover, some results of the innovative interventions being implemented in China could provide experience for HIV/AIDS prevention around the world. There will be 4 topics to be presented and discussed, including: 1) Evaluation on a comprehensive intervention targeting MSM HIV new infectious reduction in 20 cities; 2) The practice and challenges of pre-exposure prophylaxis (PrEP) against HIV infection; 3) Prevention at scale: Developing a remote-services intervention to be incorporated into a widely-used geosocial networking app for Chinese MSM;4)Acceptability of male circumcision for HIV prevention among Chinese men who have sex with men by different roles in anal sex under the context of new evidence and medical devices: a cross-sectional study.