Isabel J. Sible (United States of America)
University of Southern California
Psychology
I am a 4th year PhD candidate in Clinical Science at USC in Los Angeles, California. My research interests include physiological markers of senescence (blood pressure variability, heart rate variability), cerebrovascular disease, and Alzheimer's disease. Additionally, my research background is in emotions, physiology, and aging. Clinically, I am interested in working with older adults, older adult couples, and individuals experiencing grief.

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VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY PREDICTS CEREBROSPINAL FLUID ALZHEIMER’S DISEASE BIOMARKERS IN OLDER ADULTS

Session Name
1240 - AD, PD, LBD: MACHINE LEARNING, DEEP LEARNING, EEG, DIAGNOSIS. & CLINICAL TRIALS (ID 210)
Session Type
SYMPOSIUM
Date
Fri, 18.03.2022
Session Time
02:45 PM - 04:45 PM
Room
ONSITE: 133-134
Lecture Time
04:00 PM - 04:15 PM
Presenter

Abstract

Aims

1. Objectives: Blood pressure variability is an emerging risk factor for dementia, but mechanisms remain unclear. We examined whether visit-to-visit blood pressure variability is related to cerebrospinal fluid Alzheimer's disease biomarker levels over time, and whether associations differed by apolipoprotein ε4 carrier status.

Methods

2. Methods: 466 Alzheimer's Disease Neuroimaging Initiative participants without dementia underwent 3-4 blood pressure measurments over 12 months and >= 1 collection of cerebrospinal fluid amyloid-beta and phosphorylated tau samples thereafter. Only biomarker samples collected after the final blood pressure measurement were analyzed. Bayesian linear growth modeling investigated the role of blood pressure variability, apolipoprotein ϵ4, and the passage of time on biomarker levels after controlling for several variables, including average blood pressure and baseline hypertension.

Results

3. Results: Elevated blood pressure variability was associated with increased phosphorylated tau (ß: 3.75 [95% CI 2.12, 5.32]) and decreased amyloid-beta cerebrospinal fluid levels (ß: -2.86 [95% CI -6.05, -.33]) at follow-up. Apolipoprotein ϵ4 carriers with elevated blood pressure variability had the fastest increase in phosphorylated tau levels (ß: 19.34 [95% CI 7.80, 30.62]). Blood pressure variability was not significantly related to amyloid-beta levels over time based on ϵ4 carrier status.

Conclusions

4. Conclusions: Older adults with elevated blood pressure variability exhibit increased cerebrospinal fluid phosphorylated tau and decreased amyloid-beta over time, suggesting blood pressure variability may be a useful marker of Alzheimer’s disease progression. Apolipoprotein ϵ4 carrier status moderated the relationship between blood pressure variability and phosphorylated tau but not amyloid-beta, consistent with other studies linking hemodynamic factors to tau changes.

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