Dr. Guojun Bu is the Chair of the Department of Neuroscience at Mayo Clinic Jacksonville. He holds the academic rank of Mary Lowell Leary Professor of Medicine and Professor of Neuroscience. Dr. Bu is also the Jorge and Leslie Bacardi Associate Director of the Mayo Clinic Center for Regenerative Medicine and an Associate Director of the Mayo Clinic Alzheimer’s Disease Research Center. Prior to joining Mayo Clinic in 2010, he was a Professor of Cell Biology and Neuroscience at the Washington University School of Medicine in St. Louis. Dr. Bu received his B.S. degree in biology from Beijing Normal University, his Ph.D. degree in biochemistry from Virginia Tech, and completed his postdoctoral training in cell biology at the Washington University School of Medicine. Dr. Bu is a world leader in the field of apoE and apoE receptors, which play critical roles in the pathogenesis of Alzheimer’s disease. His primary interest is to understand why APOE4 is a strong genetic risk factor for Alzheimer’s disease and how this pathway can be targeted for therapy by studying animal and stem cell-based cellular and organoid models. His research also includes interests in addressing the pathobiology of TREM2 and the glial and vascular contributions to Alzheimer’s disease and related dementias. Dr. Bu has received numerous honors and awards including the Zenith Fellows Award from the Alzheimer’s Association, the Established Investigator Award from the American Heart Association, the Investigator of the Year award from the Mayo Clinic, and the MetLife Foundation Award for Medical Research in Alzheimer’s disease. He is an elected Fellow of the American Association for the Advancement of Science (AAAS), a Co-Editor-in-Chief of Molecular Neurodegeneration and an Associate Editor for Science Advances.