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ANALYSIS OF CERVICAL ABNORMALITIES IN A BRAZILIAN CITY AFTER IMPLEMENTATION OF QUADRIVALENT VACCINE AGAINST HPV IN GIRLS 10 TO 15 YEARS IN 2010
Abstract
Background
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract,which is why it is considered a public health problem.Campos dos Goytacazes is the first city in Brazil who introduced in 2010 the quadrivalent HPV vaccine (4vHPV) for girls 10-15 years old,4 years before public vaccination program
Aims
The ecological analysis evaluated the impact of HPV vaccination as a protective factor against HPV abnormalities
Methods
Results of the Pap smear test obtained from the Brazilian Ministry of Health’s SISCOLO System were categorized in low-grade abnormalities (LGA) and high-grade abnormalities (HGA).We analyzed results in pap tests before and 09 years after the vaccine introduction
Results
In 2009 we obtained a total of 207 LGA and 63 HGA; 2010, 143 LGA and 96 HGA anomalies; 2011, 155 LGA and 115 HGA; 2012, 152 LGA and 62 HGA; 2013, 138 LGA and 46 HGA; 2014, 86 LGA and 39 HGA; 2016, 219 LGA and 87 HGA; 2017, 313 LGA and 207 HGA; 2018, 344 LGA and 205 HGA; 2019, 599 LGA and 247 HGA
Conclusions
After implementation of 4vHPV there was a reduction in LGA e HGA.Then, in 2016, we observed an increase in the absolute number of LGA e HGA and abrupt increase in 2019,which can be correlated with the reduction in vaccination coverage caused by reduction in government advertising and incentives for vaccination,including school vaccination strategies.Other important factors are a possible replacement of the viral type or increasing sensibility in surveillance system.Other studies most be carried out to analyze this tendency