Estelle E. Seyman (Israel)
Tel- Aviv Sourasky medical center
Neurology
Dr. Seyman has graduated medical school with honors at Ben-Gurion University on 2007. She continued with an internship program followed by a residency in Neurology at the Tel-Aviv medical center. During her residency Dr. Seyman has developed an interest in advanced brain imaging in vascular and inflammatory brain pathologies. She has completed a research fellowship program at the University of Toronto performing advanced MRI analyses in neuroinflammatory brain diseases, with a special interest in high resolution T1 vessel wall imaging. Upon returning to Israel , Dr Seyman completed a second clinical fellowship program in Vascular Neurology , and is now acting as a staff neurologist and stroke attending in the stroke department of the Tel-Aviv medical center, and is the director of emergency neurology services with an emphasis on acute stroke care. Her main research interests are advanced and new imaging techniques in intracranial vasculopathies and small vessel disease, and their relation to post stroke cognitive decline.

Presenter of 1 Presentation

 Conference Calendar

INTRACRANIAL CALCIFICATION – A MARKER FOR BRAIN ATROPHY AND FUTURE POST STROKE COGNITIVE DECLINE, DATA FROM THE TABASCO PROSPECTIVE COHORT

Session Name
0510 - VCI and Dementia (ID 38)
Session Type
Free Communication Session
Date
28.10.2021, Thursday
Session Time
17:45 - 19:15
Room
FREE COMMUNICATIONS A
Presenter
Lecture Time
17:45 - 17:55

Abstract

Background and Aims

Vascular calcifications are considered to be part of active atherosclerosis. Coronary calcification have long become a prognostic marker. Calcifications of intracranial vessels(ICC) are frequently observed on non-contrast CT and their effect on post-stroke cognitive impairment(PSCI) remains unclear. Our aim was to explore the association of ICC with long-term cognitive and advanced MRI measures in a large prospective cohort of mild stroke/transient ischemic attack(TIA) patients

Methods

Data from the Tel Aviv brain acute stroke cohort(TABASCO) was analyzed. This prospective cohort study(n=575)aimed to identify predictors of PSCI. The ICC score(ICCS) on initial NCCT was calculated using a calcium quantification application. Participants underwent a 3T-MRI and comprehensive cognitive assessments at enrollment, 6, 12 and 24 months thereafter

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Results

Baseline data were available for 531 subjects(mean age 67.4 years,59.5% males). The incidence of cognitive impairment at the two-year time mark was doubled in the high ICCS group(26% vs.13.7%,p<0.001).On multiple regression analysis higher ICCS was associated with brain atrophy manifested by lower normalized white matter(WM), gray matter(GM), hippocampal and thalamic volumes(β=-0.178,β=-0.200,β=-0.137,β=-0.157;p<0.05)and with lower cognitive scores at baseline,6- and 12-month post-stroke (β-0.14,β=-0.12, β=-0.12,respectively;p<0.05). Microstructural damage, defined by DTI analysis of the normal appearing white matter(NAWM), as well as all small vessel disease(SVD) markers were significantly increased in the high ICCS group(p<0.001, p=0.002, respectively).

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Conclusions

Our findings suggest that the ICCS correlates with brain atrophy, the extent of SVD and long-term PSCI. This score, which is a readily available imaging marker, can assist in post-stroke prognostication and help provide individually tailored therapy by adjusting treatment targets in stroke survivors.

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