My research is focused on the "GUT-BRAIN Axis” in aging. We are investigating how the interaction of the microbiome and their secretory products affect the gut physiology and thereby modulate physiology of brain in diseases outcomes specifically stroke, AD and Cerebral amyloid angiopathy (CAA). The long-term goal of my research is to elucidate the role of intestinal microbiome in interfering with intestinal epithelial homeostasis causing onset and activation of chronic inflammation with respect to neurological diseases including dementia. We hope to use commensal bacteria to beneficially modify the peripheral immune response in a hope to reduce the neuroinflammation after injury of the brain. This we term as "microbial therapy" that targets mainly in reducing immune response of the gut and brain via systemic and vagal stimulation.