Pooja Khatri (United States of America)

University of Cincinnati Gardner Neuroscience Institute, University of Cincinnati Academic Health Center Neurology and Rehabilitation Medicine
Pooja Khatri is a Tenured Professor of Neurology at University of Cincinnati (UC) in the USA, Director of the UC Stroke Team and the Vascular Neurology Division, and Co-Director of the UC Gardner Neuroscience Institute Stroke Center of Excellence. She received her BSc in Biological Sciences from Stanford University and MD from University of Illinois. After neurology residency at University of Pennsylvania, Dr. Khatri completed an NIH SPOTRIAS fellowship in vascular neurology at UC. She is an NIH Career Development Award (K23) and American Heart Association (AHA) Siekert Award recipient. She also completed a Masters in clinical epidemiology at Harvard School of Public Health. Her expertise includes acute stroke, epidemiology, and clinical trials more broadly. She co-directs the NIH StrokeNet’s National Coordinating Center. Currently funded studies also include the epidemiology of brain health, clinical trials of acute reperfusion and early prevention, and acute biomarkers of recovery. She has participated in FDA advisory, ethics, and data safety and monitoring boards. She is Associate Editor of the AHA Stroke journal, member of the AHA Stroke Council Leadership, and Secretary of the World Stroke Organization. She has authored over 200 manuscripts, including national and international guidelines.

Author Of 2 Presentations

CT Perfusion in Acute Ischemic Stroke: Interpretation and Pitfalls

Session Type
Main Theme Symposium
Date
28.10.2021, Thursday
Session Time
10:00 - 11:30
Room
MAIN THEME A
Lecture Time
10:17 - 10:34

THE INFLUENCE OF NEUROLOGICAL DEFICITS ON THE EQ-5D DIMENSIONS

Session Type
Oral Presentations
Date
27.10.2021, Wednesday
Session Time
09:50 - 10:20
Room
ORAL PRESENTATIONS 2
Lecture Time
10:00 - 10:10

Abstract

Background and Aims

The EuroQol Group 5-Dimension Self-Reported Questionnaire (EQ-5D) may not cover the full range of deficits relevant to patients with ischemic stroke, such as aphasia, dysarthria, hemianopia and neglect.We aimed to quantify and compare the influence of neurological deficits on the five dimensions of the EQ-5D in patients with ischemic stroke.

Methods

We used data of the Interventional Management of Stroke (IMS) III trial. The association between neurological deficits (NIHSS sum score and individual NIHSS item scores) and each EQ-5D dimension was assessed with univariable ordinal logistic regression. The explained variance of each model was estimated with Nagelkerke’s pseudo R2.

Results

In total, 525 surviving patients were included in this study. The association between the NIHSS sum score and each EQ-5D dimension was statistically significant. The NIHSS sum score explained 54.2% of the variation in mobility, 60.0% in self-care, 56.9% in usual activities, 12.6% in pain/discomfort, and 9.2% in anxiety/depression. The explained variance in pain/discomfort was 0.5% for aphasia, 2.9% for dysarthria, 6.8% for sensory loss, 5.5% for hemianopia, and 2.9% for neglect.

Conclusions

In patients with ischemic stroke, the influence of neurological deficits on the EQ-5D dimensions mobility, self-care, and usual activities is substantial, but small on the dimensions pain/discomfort and anxiety/depression. This confirms our hypothesis that it may not be clear that discomfort caused by aphasia and neglect could be included in the dimension pain/discomfort. A small change in the way this dimension is proposed to the patient, might improve health-related quality of life assessment in stroke patients.

Hide

Presenter of 1 Presentation

CT Perfusion in Acute Ischemic Stroke: Interpretation and Pitfalls

Session Type
Main Theme Symposium
Date
28.10.2021, Thursday
Session Time
10:00 - 11:30
Room
MAIN THEME A
Lecture Time
10:17 - 10:34

Moderator of 1 Session

Session Type
Satellite Session
Date
29.10.2021, Friday
Session Time
15:15 - 16:45
Room
WSC TV
Session Icon
Pre-Recorded with Live Q&A, WSC TV