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Future of Tenecteplase
Future of IVT in Patients with LVO
Future of IVT Beyond 4,5 Hours
Abstract
Abstract Body
The EXTEND, ECASS4 and EPITHET data indicate that perfusion mismatch selection can be used to identify patients who benefit from thrombolysis beyond 4.5h after onset. However, these trials preceded the evidence for thrombectomy >6h and so we lack data on how to best combine thrombolysis and thrombectomy beyond 4.5h for the 60-70% of patients in the EXTEND trial who had a thrombectomy-eligible large vessel occlusion. This lecture will discuss the evidence to date and ongoing trials such as TIMELESS and ETERNAL.