Sofia A. Oliveira (Portugal)
USF Alvalade
Centro de Saúde de Alvalade
1. Education • 1991/6: undergraduate degree in Physics Engineering, Instituto Superior Técnico, Lisbon, Portugal. • 1996/7: Gulbenkian PhD Program in Biology and Medicine. • 1997/2000: Research Fellow, Princeton University, USA. • 1997/2002: PhD in Biomedical Sciences, Faculdade de Medicina, Universidade de Lisboa (FMUL). • 2009/16: Medical doctor degree, FMUL. • Since 2018: Family Medicine Fellow, UCSP Alvalade / USF Alvalade, ACES Lisboa Norte, ARSLVT. 2. Professional experience • 2001/4: Research Associate and Research Scientist, Center for Human Genetics, Duke University, USA. • 2004/8: Group leader, Instituto Gulbenkian de Ciência, Oeiras. • 2008/16: Group leader, Instituto de Medicina Molecular, Lisboa. • Since 2008: Invited Assistant Professor, FMUL. 3. Publications, awards and others • Co-author of 35 scientific papers published in peer-reviewed journals. • Recipient of several awards (e.g. Best Scientific Article Award, Instituto de Genética Médica Jacinto Magalhães in 2006; NEDAI Prize for Clinical Research in Auto-Immunity in 2012; Prof. Robalo Cordeiro Award in 2013; Update Medicina – Clinical and Epidemiological Research in 2018). • Co-inventor on Patent Number: US2009098557-A1.

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 Conference Calendar

LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) IN HEALTHY YOUNG ADULTS: THE LOWER THE BETTER?

Session Name
CLINICAL TOPICS I (ID 81)
Date
05.07.2021, Monday
Session Time
07:00 AM - 08:00 AM
Room
On-Demand 1 Slide 5 Mins
Presenter
Lecture Time
07:00 AM - 07:05 AM
Session Icon
On Demand

Abstract

Abstract Body

Background and purpose

Overwhelming evidence from clinical trials supports the notion that reduction in LDL-C levels with lipid-lowering agents reduces the risk of developing cardiovascular diseases (CVD) and CVD mortality. However, in the elderly, systematic reviews1,2 of cohort studies revealed that lower LDL-C levels are associated with higher all-cause mortality, the so called LDL paradox. Our aim was to revisit the association of LDL-C levels with overall mortality in cohorts of healthy younger adults.

Methods

The authors independently searched PubMed for cohort studies with the following keywords: (low-density lipoprotein OR low density lipoprotein) AND mortality NOT animal NOT trial. We excluded non-English reports, studies in geriatric populations or high cardiovascular risk groups, and papers with electronic publication date before 1/1/2010 or after 10/2/2021.

Results

We identified 2 papers including 639.157 individuals from 3 cohorts where all-cause mortality was recorded. In all 3 cohorts, the association between LDL-C levels and the risk of overall mortality was U-shaped, with individuals with LDL-C<70mg/dL having a significantly higher risk for all-cause mortality.

Conclusions

These controversial findings suggest that LDL-C levels below 70mg/dL may be detrimental in the general adult population not taking statins. Further studies are required to understand the mechanism behind this LDL paradox in healthy young adults and in the elderly.

References

1Ravnskov et al. BMJ Open 2016; 6(6):e010401.

2 Oliveira et al. European Geriatric Medicine 2020; 11:S155.

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