Poster display Poster Display session

109P - Multiphysics modelling of alpha-immuno-conjugate delivery and background dose

Presentation Number
109P
Lecture Time
17:10 - 17:10
Speakers
  • Tong Liu (chalk river, ontario, CA)
Session Name
Poster display
Location
Foyer La Scene, Paris Marriott Rive Gauche, Paris, France
Date
05.03.2018
Time
17:10 - 18:00
Authors
  • Tong Liu (chalk river, ontario, CA)

Abstract

Background

Radiotherapy is one of the commonly used approaches to treat cancer. The research trend and breakthroughs in radiotherapy is focusing on the high linear energy transfer (LET) radiation like the alpha particles. Thus, the alpha particles based method is an important option of radiotherapy development, and Targeted Alpha Therapy (TAT) is the most important application of using alpha particles in the past decade. This paper highlights the research work done on computational modelling of TAT at Canadian Nuclear Laboratories (CNL).

Methods

Mathematical model is developed to study the blood flow through a two-dimensional vasculature embedded in a solid tumour or a normal cell. A mesoscale modeling (with a length scale of 1 µm – 1mm and a time scale of 1 ns - 1 µs) is conducted in order to gain an understanding of dynamic alpha-immuno-conjugate (AIC)-attached blood flow interaction in vasculature and its influence on AIC motion in the main flow direction and the perturbations/instabilities of the AIC trajectories in the transverse direction. Microdosimetic modeling of TAT using Monte Carlo toolkit to calculate the amounts of the energy deposited in a simplified DNA model of cancer cells and evaluate the absorbed background dose for normal cells. Coupled the computational fluid dynamic (CFD) simulation with the Monte Carlo prediction to evaluate the efficacy of the AIC during transport process of killing tumour cells and the toxicity to the surrounding normal cells. Post-processing large amount of data calculated by high fidelity CFD simulation and microdosimetric analysis and help review the efficacy of the TAT treatment that is invisible in experiment in pre-clinical stage using a powerful visualization tool.

Results

A coupled model based on the Geant4 Monte Carlo micro-dosimetry technique and Computational Fluid Dynamics analysis was established. The transient drug delivery process and background dose to the cells along the pathway were investigated. A mesoscale numerical simulation in a simple 2D capillary was performed to determine the transient toxicity of the Alpha-Immuno-Conjugate to the DNA of a targeted cell.

Conclusions

The paper demonstrates the feasibility of coupling CFD simulations and microdosimetic modeling to evaluate the efficacy of the TAT realistically and accurately.

Legal entity responsible for the study

Canadian Nuclear Laboratories (CNL)

Funding

Has not received any funding

Disclosure

The author has declared no conflicts of interest.

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