Author Of 1 Presentation
P0799 - Cognitive impairment in pediatric multiple sclerosis: the age of onset as a probable predictive variable. (ID 1636)
Abstract
Background
Pediatric-onset Multiple sclerosis (MS) disorder, due to its severity, usually leads to various forms of cognitive decline in a variety of domains. Generally, with the early age of manifestation, there is a decline in several cognitive functions such as memory, information processing speed, attention, and executive functions. Childhood sample is characterized by the persistence of disfunction in various spheres of language, if compared to adults group with MS, The age of onset, the disease duration, and frequency of relapses are not only related with the accumulation of persistently neurological deficits but also with the rate of cognitive decline.
Objectives
The aim of the study was focused on the evaluation of cognitive processing in patients with pediatric-onset MS. Moreover special attention was made on estimation of its possible interrelations with clinical characteristics as the age of manifestation and the disease longevity.
Methods
The study included 45 patients with pediatric multiple sclerosis. All patients were consulted by a loclal neurologist with EDSS assessment and MRI scanning. To evaluate cognitive functioning rates, a thorough examination via Luria’s Neuropsychological Tests and psychometric methods were included. Special attention was paid to measuring attention, executive functions, memory, verbal fluency, and overall intellectual functioning.
Results
Using factor analysis, we found some main factors, which represent a set of certain symptom complexes of cognitive decline in children and adolescents with MS. These factors consist of such cognitive domains as attention, executive functions, verbal and visuospatial memory, and various spheres of language. It was found that the sample with the early age of onset (from 5 to 8 years) is more vulnerable to verbal fluency and executive function impairment in comparison to the sample of children with a manifestation in adolescence from 13 to 16 years.
Conclusions
As results showed an early onset of MS makes patients more vulnerable to cognitive decline and subsequent disability, which raises questions of early diagnosis procedures. Specifically, it seems perspective, to focus on an examination of language, memory, executive function performance, to bring personalized treatment and rehabilitation programs at the most crucial time.
Presenter Of 1 Presentation
P0799 - Cognitive impairment in pediatric multiple sclerosis: the age of onset as a probable predictive variable. (ID 1636)
Abstract
Background
Pediatric-onset Multiple sclerosis (MS) disorder, due to its severity, usually leads to various forms of cognitive decline in a variety of domains. Generally, with the early age of manifestation, there is a decline in several cognitive functions such as memory, information processing speed, attention, and executive functions. Childhood sample is characterized by the persistence of disfunction in various spheres of language, if compared to adults group with MS, The age of onset, the disease duration, and frequency of relapses are not only related with the accumulation of persistently neurological deficits but also with the rate of cognitive decline.
Objectives
The aim of the study was focused on the evaluation of cognitive processing in patients with pediatric-onset MS. Moreover special attention was made on estimation of its possible interrelations with clinical characteristics as the age of manifestation and the disease longevity.
Methods
The study included 45 patients with pediatric multiple sclerosis. All patients were consulted by a loclal neurologist with EDSS assessment and MRI scanning. To evaluate cognitive functioning rates, a thorough examination via Luria’s Neuropsychological Tests and psychometric methods were included. Special attention was paid to measuring attention, executive functions, memory, verbal fluency, and overall intellectual functioning.
Results
Using factor analysis, we found some main factors, which represent a set of certain symptom complexes of cognitive decline in children and adolescents with MS. These factors consist of such cognitive domains as attention, executive functions, verbal and visuospatial memory, and various spheres of language. It was found that the sample with the early age of onset (from 5 to 8 years) is more vulnerable to verbal fluency and executive function impairment in comparison to the sample of children with a manifestation in adolescence from 13 to 16 years.
Conclusions
As results showed an early onset of MS makes patients more vulnerable to cognitive decline and subsequent disability, which raises questions of early diagnosis procedures. Specifically, it seems perspective, to focus on an examination of language, memory, executive function performance, to bring personalized treatment and rehabilitation programs at the most crucial time.