Author Of 1 Presentation
P0259 - Multiple Sclerosis, variant Marburg, an uncommon form: about a case. (ID 1158)
Abstract
Background
Marburg disease is an inflammatory demyelinating syndrome related to multiple sclerosis (MS) with different clinical, radiological and pathological presentation, belonging to the swelling variants. The clinical presentation varies from paucisymptomatic patients to others with confusion, hemiparesis, hemineglect syndrome or epileptic seizures.
Objectives
Given its malignant course and infrequency, the objective of this study is to review the literature on the diagnosis and management of a case.
Methods
We present the case of a 34-year-old woman, with no history of interest, who attended the Emergency Department in September 2019 for two episodes compatible with secondary, complex generalized seizures and headache. She also has intermittent paresthesias in the right lower limb associated with tonic contraction for 8 months. In its follow-up, development of asymmetric paraparesis with right predominance and dyslexic cognitive disorder has been observed.
Results
Cranial CT: three bilateral subcortical hypodense focal lesions. Neurological examination: normal at the start of the study. MRI September 2019: multiple bilateral lesions with enhancement, edema and mass effect (22mm the largest), associating spinal cord injuries, suggesting swelling demyelinating origin. EEG: abnormal. CSF: normal. CSF PCRs: negative. Autoimmunity: no findings. Neurotropic virus serologies: negative. Treatment with Lacosamide 50mg / 12 hours begins, no new crises have occurred since November 2019. MRI January 2020: multiple new enhancing lesions (from 19 to 50). Following diagnosis, steroid boluses have been prescribed and treatment with Ocrelizumab (positive anti-JC Acs) will begin.
Conclusions
The clinical course of the Marburg variant is unpredictable, sometimes with poor clinical-radiological correlation as indicated in the literature. It is very important to take it into account in the differential diagnosis of demyelinating diseases and of these with swelling-like neoplastic lesions for their adequate follow-up and early treatment.
Presenter Of 1 Presentation
P0259 - Multiple Sclerosis, variant Marburg, an uncommon form: about a case. (ID 1158)
Abstract
Background
Marburg disease is an inflammatory demyelinating syndrome related to multiple sclerosis (MS) with different clinical, radiological and pathological presentation, belonging to the swelling variants. The clinical presentation varies from paucisymptomatic patients to others with confusion, hemiparesis, hemineglect syndrome or epileptic seizures.
Objectives
Given its malignant course and infrequency, the objective of this study is to review the literature on the diagnosis and management of a case.
Methods
We present the case of a 34-year-old woman, with no history of interest, who attended the Emergency Department in September 2019 for two episodes compatible with secondary, complex generalized seizures and headache. She also has intermittent paresthesias in the right lower limb associated with tonic contraction for 8 months. In its follow-up, development of asymmetric paraparesis with right predominance and dyslexic cognitive disorder has been observed.
Results
Cranial CT: three bilateral subcortical hypodense focal lesions. Neurological examination: normal at the start of the study. MRI September 2019: multiple bilateral lesions with enhancement, edema and mass effect (22mm the largest), associating spinal cord injuries, suggesting swelling demyelinating origin. EEG: abnormal. CSF: normal. CSF PCRs: negative. Autoimmunity: no findings. Neurotropic virus serologies: negative. Treatment with Lacosamide 50mg / 12 hours begins, no new crises have occurred since November 2019. MRI January 2020: multiple new enhancing lesions (from 19 to 50). Following diagnosis, steroid boluses have been prescribed and treatment with Ocrelizumab (positive anti-JC Acs) will begin.
Conclusions
The clinical course of the Marburg variant is unpredictable, sometimes with poor clinical-radiological correlation as indicated in the literature. It is very important to take it into account in the differential diagnosis of demyelinating diseases and of these with swelling-like neoplastic lesions for their adequate follow-up and early treatment.