Author Of 1 Presentation
P1032 - Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with MS, irrespective of MS phenotype (ID 761)
Abstract
Background
The symptoms that have the largest impact on health-related quality of life (HRQoL) in people with multiple sclerosis (MS) may vary by MS phenotype (relapsing-remitting MS, RRMS; secondary progressive MS, SPMS; primary progressive MS, PPMS). Knowing these symptoms assists in symptom management.
Objectives
To examine the associations between 13 common MS symptoms and HRQoL in the total sample and stratified by MS phenotype.
Methods
The study included 1,985 participants. HRQoL was measured with two multi-attribute utility instruments: Assessment of Quality of Life with eight dimensions (AQoL-8D) and European Quality of Life with five dimensions and five levels (EQ-5D-5L). Multivariable linear regression was used to identify the symptoms that had the largest impact on the HRQoLs.
Results
Feelings of depression, pain, fatigue, and feelings of anxiety were most strongly associated with AQoL-8D and EQ-5D-5L. Walking difficulties additionally contributed to reduced EQ-5D-5L. The strongest single predictors were feelings of depression or pain for AQoL-8D and walking difficulties for EQ-5D-5L, irrespective of MS phenotype.
Conclusions
The strongest single predictors for the AQoL-8D and EQ-5D-5L were feelings of depression, pain, and walking difficulties, irrespective of MS phenotype. Reducing these symptoms may have the largest impact on improving HRQoL in all MS phenotypes of people with MS.
Presenter Of 1 Presentation
P1032 - Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with MS, irrespective of MS phenotype (ID 761)
Abstract
Background
The symptoms that have the largest impact on health-related quality of life (HRQoL) in people with multiple sclerosis (MS) may vary by MS phenotype (relapsing-remitting MS, RRMS; secondary progressive MS, SPMS; primary progressive MS, PPMS). Knowing these symptoms assists in symptom management.
Objectives
To examine the associations between 13 common MS symptoms and HRQoL in the total sample and stratified by MS phenotype.
Methods
The study included 1,985 participants. HRQoL was measured with two multi-attribute utility instruments: Assessment of Quality of Life with eight dimensions (AQoL-8D) and European Quality of Life with five dimensions and five levels (EQ-5D-5L). Multivariable linear regression was used to identify the symptoms that had the largest impact on the HRQoLs.
Results
Feelings of depression, pain, fatigue, and feelings of anxiety were most strongly associated with AQoL-8D and EQ-5D-5L. Walking difficulties additionally contributed to reduced EQ-5D-5L. The strongest single predictors were feelings of depression or pain for AQoL-8D and walking difficulties for EQ-5D-5L, irrespective of MS phenotype.
Conclusions
The strongest single predictors for the AQoL-8D and EQ-5D-5L were feelings of depression, pain, and walking difficulties, irrespective of MS phenotype. Reducing these symptoms may have the largest impact on improving HRQoL in all MS phenotypes of people with MS.