Author Of 1 Presentation
P1078 - Obesity in pediatric onset multiple sclerosis: a French cohort study (ID 695)
Abstract
Background
Pediatric onset multiple sclerosis (POMS) is a multifactorial disease involving genetical and environnemental factors, among which obesity is thought to play a major role.
Objectives
To study the presumed link between a high body mass index (BMI) in childhood and the occurrence of pediatric onset MS and to compare, within the MS population, the clinical-radiological-biological characteristics, according to the corpulence of each patient.
Methods
A case-control study including BMI data of 60 pediatric MS patients followed at Bicêtre University hospital to that of 113 non neurological patients (controls) and 27287 healthy French children (healthy controls, extracted from the study by Scherdel et al, 2015) was performed. Crude BMI, residual BMI (expected BMI for age based on healthy controls -measured BMI), and adult equivalent categories (AEC>25=overweight, AEC>30=obese) were assessed.
Results
In boys, both crude and residual BMI were significantly higher in MS children (39 girls, 21 boys, mean age 13.7) compared to controls (69 girls, 44 boys, mean age 13.8) with crude BMI +3.9 and residual BMI +2.9, p<0.01; and healthy controls (13533 girls, 13754 boys; p<0.01). BMI AEC>30 (p=0.007) and AEC>25 (p=0.005) at first hospitalization were significantly higher in boys with MS than controls .
In girls, there was no significant difference in crude BMI or residual BMI between MS girls and controls (crude BMI:p=0.38; residual BMI +0.97; p=0.12) or healthy controls (crude BMI:p=0.054) with a slight tendency for increased BMI in MS patients.
Inflammatory CSF markers (oligoclonal bands, hypercellularity or hyperproteinorachia) correlated positivily with BMI in prepubertal patients (p<0.01) while vitamin D level at onset of disease decreased with BMI in boys (p=0.01). Increased BMI was not associated with the annual relapse rate, age at onset or initial clinical and radiological characteristics.
Conclusions
Overweight and obesity are observed more frequently in boys with MS at the time of diagnosis compared to a local control and the French pediatric population. In contrast to what has already been published, overweight and obesity are not more frequent in girls with MS, despite a trend towards a higher initial BMI. Increased CSF inflammation in overweighed prepubertal patients and involvement of mostly boys may suggest involvement of androgenic hormones in the pathogenesis of POMS in this particular group of patients.
Presenter Of 1 Presentation
P1078 - Obesity in pediatric onset multiple sclerosis: a French cohort study (ID 695)
Abstract
Background
Pediatric onset multiple sclerosis (POMS) is a multifactorial disease involving genetical and environnemental factors, among which obesity is thought to play a major role.
Objectives
To study the presumed link between a high body mass index (BMI) in childhood and the occurrence of pediatric onset MS and to compare, within the MS population, the clinical-radiological-biological characteristics, according to the corpulence of each patient.
Methods
A case-control study including BMI data of 60 pediatric MS patients followed at Bicêtre University hospital to that of 113 non neurological patients (controls) and 27287 healthy French children (healthy controls, extracted from the study by Scherdel et al, 2015) was performed. Crude BMI, residual BMI (expected BMI for age based on healthy controls -measured BMI), and adult equivalent categories (AEC>25=overweight, AEC>30=obese) were assessed.
Results
In boys, both crude and residual BMI were significantly higher in MS children (39 girls, 21 boys, mean age 13.7) compared to controls (69 girls, 44 boys, mean age 13.8) with crude BMI +3.9 and residual BMI +2.9, p<0.01; and healthy controls (13533 girls, 13754 boys; p<0.01). BMI AEC>30 (p=0.007) and AEC>25 (p=0.005) at first hospitalization were significantly higher in boys with MS than controls .
In girls, there was no significant difference in crude BMI or residual BMI between MS girls and controls (crude BMI:p=0.38; residual BMI +0.97; p=0.12) or healthy controls (crude BMI:p=0.054) with a slight tendency for increased BMI in MS patients.
Inflammatory CSF markers (oligoclonal bands, hypercellularity or hyperproteinorachia) correlated positivily with BMI in prepubertal patients (p<0.01) while vitamin D level at onset of disease decreased with BMI in boys (p=0.01). Increased BMI was not associated with the annual relapse rate, age at onset or initial clinical and radiological characteristics.
Conclusions
Overweight and obesity are observed more frequently in boys with MS at the time of diagnosis compared to a local control and the French pediatric population. In contrast to what has already been published, overweight and obesity are not more frequent in girls with MS, despite a trend towards a higher initial BMI. Increased CSF inflammation in overweighed prepubertal patients and involvement of mostly boys may suggest involvement of androgenic hormones in the pathogenesis of POMS in this particular group of patients.