Approximately a quarter of people with MS are mature adults over 65 years old and this number is rising as Baby Boomers age. Older persons with MS have different care needs than their younger counterparts. They must adjust to the normal age-related changes as they age and at the same time manage and adapt to increasing disability related to MS. Health care providers must know differences between normal aging and progression of MS and understand the changing health care needs of the older person with MS. This presentation will focus on clinical implications in caring for older persons with MS.