E. Martinez-Lapiscina

Elena H. Martínez-Lapiscina was born in 1982 in Vitoria-Gasteiz, Spain. She earned a MD at University of Navarra School of Medicine in Pamplona, Spain in 2006. She won a Special Mention at the National Spanish Medical Degree Award Commission (2005-2006) by the Ministry of Education and Science, Spain. After achieving the first position in the national wide examination for accessing to a medical residency, she completed a neurology residency in 2012 in Pamplona Spain. In 2013, Elena H Martínez-Lapiscina received her PhD in Neurosciences & Cognition at the University of Navarra School of Medicine, Pamplona Spain. Finally, she obtained a MPH-Epidemiology at Harvard School of Public Health, Boston, US in 2019.

As part of her academic career, she has worked as a neurologist and researcher (clinical and imaging) in Neurosciences Service in the Hospital Clinic – IDIBAPS of the University of Barcelona (2012-2019). She has also performed short stages in the Pitié-Salpêtrière Hospital (neuromuscular unit), University of California San Francisco (UCSF) (neuroimmunology and neuro-ophthalmology), Harvard School of Public Health (neuroepidemiology). She has published 71 articles and participated as PI or collaborator in more than 25 international and national projects pursuing the development of markers for easing drug development for CNS conditions.

Since 2019, she works as Topic Lead of Immune-mediated and rare neurological disorders and clinical neurologist in the Office of therapies for neurological and psychiatric disorders (H-NEU) in the Human Medicines (H-Division) in the European Medicines Agency (EMA).

Author Of 1 Presentation

Neuromyelitis Optica and Anti-MOG Disease Oral Presentation

PS15.03 - Optical coherence tomography in aquaporin-4-IgG positive neuromyelitis optica spectrum disorders: a collaborative multi-center study

Abstract

Background

Optic neuritis (ON) is a frequent manifestation in aquaporin-4 antibody (AQP4-IgG) seropositive neuromyelitis optica spectrum disorders (NMOSD). Due to limited samples, existing optical coherence tomography (OCT) studies are inconsistent regarding retinal changes in eyes with a history of ON (NMO-ON) and without a history of ON (NMO-NON), and their functional relevance.

Objectives

The CROCTINO (Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica) project aims to reveal correlates of retinal pathology and to generate hypotheses for prospective OCT studies in NMOSD. The objective of this study was to analyze retinal changes of AQP4-IgG seropositive NMO-ON and NMO-NON eyes in an international cross-sectional OCT dataset.

Methods

Of 656 subjects, we enrolled 283 AQP4-IgG seropositive NMOSD patients and 72 healthy controls (HC) from 22 international expert centers. OCT data was acquired with Spectralis SD-OCT, Cirrus HD-OCT and Topcon 3D OCT-1. Mean thickness for the combined ganglion cell and inner plexiform layer (GCIP) and inner nuclear layer (INL) were calculated from macular volume scans. Clinical, functional and laboratory testing were performed at discretion of each center.

Results

We compared NMO-ON eyes (N = 260), NMO-NON eyes (N = 241) and HC eyes (N = 136). GCIP was reduced in NMO-ON (57.4 ± 12.2 µm) compared with NMO-NON (75.9 ± 7.7 µm; p < 0.001) and HC (81.4 ± 5.7 µm; p < 0.001). NMO-NON had thinner GCIP (p < 0.001) compared with HC. INL was thicker in NMO-ON (40.3 ± 3.9 µm) compared with NMO-NON (38.6 ± 3.9µm; p < 0.001), but not HC (39.4 ± 2.6 µm). Microcystic macular edema were visible in 6.6 % of NMOSD eyes.

Conclusions

AQP4-IgG seropositive NMOSD is characterized by a functionally relevant loss of retinal neuroaxonal content and a - probably inflammatory - increase of INL after ON. Our study further supports the existence of attack-independent damage in the visual system of patients with AQP4-IgG seropositive NMOSD.

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