Wa Ode Dwi Daningrat (Indonesia)
University of Oxford
Nuffield Department of Medicine, Big Data Institute
Wa Ode Dwi Daningrat is an Indonesian government (Ministry of Education, Culture, Research, and Technology & The Indonesia Endowment Funds for Education) scholar pursuing a DPhil in Clinical Medicine at the University of Oxford. Her DPhil research focuses on the genomic epidemiology of Streptococcus pneumoniae pre- and post- Pneumococcal Conjugate Vaccine Introduction in Indonesia. Her main interests are the antimicrobial resistance (AMR) of Streptococcus pneumoniae and the utilisation of whole-genome sequencing (WGS) to investigate the presence of genes and mutations in pneumococcal isolates related to AMR. Following graduation from the University of Indonesia, she has been involved in several collaborative projects with the US-CDC since 2016 on pneumococcal carriage study, vaccine impact evaluation, and AMR profiling in Indonesia. She received the 2018 International Society for Infectious Diseases (ISID) Research Grant Award for her research on the AMR profile of Streptococcus pneumoniae. She was granted an award in AMR by ISID and the Center for Disease Dynamics, Economics and Policy (CDDEP) for this work in 2019.

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 Conference Calendar

O092 - PREVALENCE, SEROTYPE DISTRIBUTION AND ANTIMICROBIAL RESISTANCE PROFILE OF STREPTOCOCCUS PNEUMONIAE IN SEA NOMADS CHILDREN UNDER 5 YEARS OF AGE IN WAKATOBI ISLANDS, INDONESIA (ID 290)

Session Name
0760 - Parallel Session 11: New Perspectives on Pneumococcal Colonization (ID 65)
Session Type
Parallel Session
Date
Wed, 22.06.2022
Session Time
15:05 - 16:35
Room
Grand Ballroom West
Presenter
Lecture Time
16:10 - 16:20

Abstract

Background

Bajau tribe known as ‘Sea Nomads’ was originated from Malay Peninsula of Southeast Asia. Wakatobi, Indonesia, hosts several of Bajau settlements where the tribe inhabited the coast and build semi-permanent houses overwater. Remote settlements and supernatural believes are among the factors to lack of access to health care in this tribe. The people commonly live in crowded house with impoverished living conditions and poor hygiene. Extremely limited data available on pneumococcal carriage and serotype distribution in Sea Nomads population.

Methods

We enrolled children <5 years old in the settlements of Bajau Tribe (Sea Nomads Tribe) located in Wakatobi Islands, Indonesia from October 2018 to February 2019. Nasopharyngeal (NP) swabs were evaluated for colonization of S. pneumoniae using molecular method, serotyping with multiplex-PCR and antimicrobial susceptibility test with disc-diffusion. Logistic regression was performed for potential risk factors analysis.

Results

We collected 499 NP swabs. 61.1% were colonized with S. pneumoniae. 47.6% of the isolates were PCV13-type. Serotype 6A/B, 23F and 19F were the most common with 17.5%, 13.8% and 8.7%, respectively. Multi-drug resistance S. pneumoniae was 40.4%. Cigarette smoke and rhinorrhea were significant risk factors to colonization with OR 1.6 (1.1 – 2.3) and 2.1 (1.4 – 3.3), respectively. Firewood has higher risk to colonization compare to LPG/Gas with OR 4.0 (1.2 - 13.5).

Conclusions

S. pneumoniae resistance was observed to commonly used antibiotics. Most of the isolates were vaccine-type. This result may contribute to evidence-based for decision making policy on vaccination and antibiotics use in Indonesia.

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