Boston Medical Center
Pediatric Infectious Diseases
Stephen I. Pelton is Professor of Pediatrics at Boston University Schools of Medicine in Massachusetts. He is the former Director of Pediatric Infectious Diseases at Boston Medical Center (BMC) and Coordinator of Maternal Child HIV Program. Professor Pelton received his medical degree from the State University of New York, Buffalo School of Medicine. He completed a residency in pediatrics at BMC and fellowship in pediatric infectious diseases at Harvard Medical School at the Channing Laboratory at Boston City Hospital. He is board certified in Pediatric Infectious Diseases and Pediatrics by the American Board of Pediatrics. Professor Pelton is an active clinician, investigator, a member of the Boston Medical University Campus Institutional Review Board, and mentor for trainees in pediatric infectious diseases at Boston Medical Center. His laboratory is focused on vaccine-preventable diseases, especially those due to Streptococcus pneumonia, and new vaccines for prevention of respiratory tract infection due to nontypeable Haemophilus influenzae. Professor Pelton’s work has led to his recognition as a leading clinical scientist in studies of the impact of pneumococcal conjugate vaccine on invasive and respiratory tract disease in children. Recent studies include studies of immunogenicity and safety of pneumococcal conjugate vaccines in HIV infected children, studies of immunogenicity and safety of a novel pneumococcal conjugate vaccine (adjuvanted with MPL) in infants, as well as studies of the burden of pneumococcal disease in children and adults with comorbid conditions. He has authored more than 150 manuscripts including publications in The New England Journal of Medicine, Clinical Infectious Diseases, The Journal of Pediatrics, Vaccine, and Pediatric Infectious Disease Journal.

Presenter of 3 Presentations

Faculty Panel Discussion and Q&A Session (ID 936)

Reducing the Burden of Pneumococcal Disease: Impact of Pneumococcal Conjugate Vaccines (ID 932)

Session Type
Industry-Sponsored Symposium
Date
Mon, 20.06.2022
Session Time
07:15 - 08:45
Room
Grand Ballroom Centre
Lecture Time
07:25 - 07:45

O067 - SEASONAL PATTERN OF INVASIVE PNEUMOCOCCAL DISEASE [IPD] IN MASSACHUSETTS’ CHILDREN DISRUPTED BY COVID19 (ID 889)

Session Type
Parallel Session
Date
Wed, 22.06.2022
Session Time
15:05 - 16:50
Room
Grand Ballroom Centre
Lecture Time
17:39 - 17:47

Abstract

Background

IPD in children in Massachusetts traditionally follows a seasonal pattern with peak disease between October-April and a nadir during June-September (Figure 1). To further understand the decline in IPD observed in 2020 and 2021, we evaluated the seasonal pattern of IPD during the multiple COVID-19 surges in Massachusetts and compared with the seasonality observed in 2002-2019

Methods

A statewide, population-based surveillance for IPD in children <18-year-old was initiated in October/2001 and has been ongoing. IPD is defined as isolation of S. pneumoniae from a normally sterile site. Microbiology laboratories submit isolates of S. pneumoniae from normally sterile body fluids to MDPH, demographic data is confirmed with follow-up phone interviews. Isolates are serotyping using antisera from Staten's Serum Institute.

Results

Forty-five cases of IPD were identified in Massachusetts’ children in 2020/21 representing a decline of 39% in annual cases compared to 2013-2019 period. Notable was the near absence of IPD cases between April/2020 and June/2021 during the peak COVID-19 activity (October/2020 to June/2021)Despite high COVID-19 activity in September-December 2021, we observed frequent IPD cases. The difference between the two period of high COVID-19 activity was the return of RSV to the community during September–December 2021.ipd isppd22 figure.jpg

Conclusions

The disruption impact of COVID-19 on IPD in Massachusetts during 2020-2021 was manifest by a 40% decline in cases in children and a disruption of the traditional seasonal pattern. The return of IPD during fourth quarter 2021 despite a COVID-19 surge was associated with a return of RSV to the community.

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