Presenter of 3 Presentations
Faculty Panel Discussion and Q&A Session (ID 936)
Reducing the Burden of Pneumococcal Disease: Impact of Pneumococcal Conjugate Vaccines (ID 932)
O067 - SEASONAL PATTERN OF INVASIVE PNEUMOCOCCAL DISEASE [IPD] IN MASSACHUSETTS’ CHILDREN DISRUPTED BY COVID19 (ID 889)
Abstract
Background
IPD in children in Massachusetts traditionally follows a seasonal pattern with peak disease between October-April and a nadir during June-September (Figure 1). To further understand the decline in IPD observed in 2020 and 2021, we evaluated the seasonal pattern of IPD during the multiple COVID-19 surges in Massachusetts and compared with the seasonality observed in 2002-2019
Methods
A statewide, population-based surveillance for IPD in children <18-year-old was initiated in October/2001 and has been ongoing. IPD is defined as isolation of S. pneumoniae from a normally sterile site. Microbiology laboratories submit isolates of S. pneumoniae from normally sterile body fluids to MDPH, demographic data is confirmed with follow-up phone interviews. Isolates are serotyping using antisera from Staten's Serum Institute.
Results
Forty-five cases of IPD were identified in Massachusetts’ children in 2020/21 representing a decline of 39% in annual cases compared to 2013-2019 period. Notable was the near absence of IPD cases between April/2020 and June/2021 during the peak COVID-19 activity (October/2020 to June/2021)Despite high COVID-19 activity in September-December 2021, we observed frequent IPD cases. The difference between the two period of high COVID-19 activity was the return of RSV to the community during September–December 2021.
Conclusions
The disruption impact of COVID-19 on IPD in Massachusetts during 2020-2021 was manifest by a 40% decline in cases in children and a disruption of the traditional seasonal pattern. The return of IPD during fourth quarter 2021 despite a COVID-19 surge was associated with a return of RSV to the community.