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O056 - ANTIMICROBIAL RESISTANCE OF STREPTOCOCCUS PNEUMONIAE ISOLATES CAUSING INVASIVE PNEUMOCOCCAL DISEASE IN 17 HOSPITALS OF COLOMBIA. (ID 581)
Abstract
Background
Invasive Pneumococcal Disease (IPD) is a cause of morbidity and mortality in children. Some Streptococcus pneumoniae isolates are resistant to antibiotics used for IPD, such as beta-lactams and macrolides.
Methods
Ambispective case series study in pediatric patients with IPD admitted in 10 hospitals of Bogotá in 2008-2021, and 4 hospitals of Cali, 2 of Medellin and 1 of Cartagena in 2017-2021(preliminary data).
Results
739 cases of IPD were found. Susceptibility profile information was obtained for 649(87.8%) isolates; 581(78.6%) were non-meningeal (NM) and 68(9.2%) meningeal (M). Regarding to NM isolates, the penicillin-resistance, increased from 9.4% (13/138) in 2008-2011 to 19.7% (19/96) in 2012-2014 and to 22.1% (77/347) in 2015-2021, the resistant to ceftriaxone was 1.4% (2/138) in 2008-2011; 1.04% (1/96) in 2012-2014 and 9.2% (32/347) in 2015-2021. M showed 20% resistance to penicillin, 4.5% resistance to ceftriaxone, and 4.5% intermediate susceptibility. Resistance to macrolides was 33.9%, to clindamycin 24.7%, and to trimethoprim sulfa 30%. All isolates were susceptible to vancomycin. Only 40% of the isolates were susceptible to all antibiotics; 9% were multi-resistant. The serotype most resistant to penicillin was 19A (24.4%), which was associated with multiresistance.
Conclusions
An increase in antibiotic resistance to penicillin and ceftriaxone is observed over time in this study associated with emergence of multiresistant Streptococcus pneumoniae serotype 19A.