Ayk Oganesyan,
Author Of 1 Presentation
SEROTYPE CHARACTERIZATION OF STREPTOCOCCUS PNEUMONIAE IDENTIFIED IN MENINGITIS CASES IN SEVERAL ASIAN AND EUROPEAN COUNTRIES (ID 896)
Abstract
Background
We examined the serotype distribution patterns of pneumococcal meningitis in the following countries: Ukraine, Belarus, Azerbaijan, Armenia, Georgia and Uzbekistan. The study was performed within the program for Invasive Bacterial Diseases Sentinel Surveillance implemented in the region by WHO Regional Office for Europe.
Methods
Cerebrospinal fluid samples (CSFs) were collected from patients with suspected meningitis at sentinel hospitals within 2007 – 2017. S. pneumoniae serogroups/serotypes in positive CSFs were determined using qPCR and mPCR. Overall, 2980 CSFs from patients aged under 5 years were tested.
Results
173 (5, 8%) CSFs were positive for S. pneumoniae. Pneumococcal serotypes/serogroups were determined in 77,5% (134) of positive CSFs, 22,5% were not-typeable. 27 serotypes/serogroups were identified. Serotypes 6A/B (17,3%), 14 (15,6%), 19F (13%), 23F (5,8%), 18A/B/C (4,6%), were the most prevalent, followed by others with a prevalence of 2% and less (9V/9A, 4, 6C/6D, 24A/B/F,19A, 5, 3, 1, 23A, 20, 2, 13, 31, 8, 7F/7A, 7C/7B/40, 22F/22A, 21, 15B/15C, 12F/12A/12B/44/46, 11A/11D, 16F).
Conclusions
The proportion of vaccine serotypes amounts to 60, 5% for PCV10 and 64,1% for PCV13, suggesting that the introduction of the conjugate vaccine is feasible and justifiable. Ongoing surveillance is needed to monitor the dynamics of serotype distribution following the introduction of PCVs.