Fernando Artiles-Campelo, Spain
Hospital Universitario de Gran Canaria Dr. Negrín MicrobiologyAuthor Of 1 Presentation
HIGH INCIDENCE OF PRIMARY IMMUNODEFICIENCIES IN PATIENTS HOSPITALIZED FOR INVASIVE PNEUMOCOCCAL DISEASES (ID 865)
Abstract
Background
Introduction. Some primary immunodeficiencies (PIDs) confer predisposition to invasive pneumococcal disease (IPD).
Methods
Methods. Identification of pediatric patients with IPD (January 2000-February 2017). Clinical and epidemiologic data and immunological explorations.
Results
Results.We identified 209 children who suffered from IPD, of whom 78 patients (mean age 34 months; range, 0 days-13 years) required hospitalization. Sixteen of the 78 children (20.5%) had classical risk factors. Immunological evaluation could be performed to 44 patients. Eight patients suffered from a PID: IRAK-4 deficiency (1 patient), X- linked agammaglobulinemia (1), congenital asplenia (2), Ataxia-telangiectasia (1), DiGeorge Syndrome (1), Charge Syndrome (1), and partial Chromosome 16 trisomy with low numbers of switched-memory B cells and hypogammaglobulinemia (1). Only two patients had recurrent IPD, and 6/8 patients did not have a clinical history suggestive of PID. In 6 of the 8 patients with PID no serious infections were recorded after diagnosis.
Conclusions
Conclusions. Around 18% of pediatric cases hospitalized with IPD may be due to a PID. Prompt diagnosis and treatment after one episode of hospitalization for IPD, even in the absence of previous severe and/or recurrent infections, protect against posterior serious infections in patients with PID.