Chittaranjan Roy, India
Darbhanga Medical College and Hospital Community MedicineAuthor Of 1 Presentation
EFFECT OF PNEUMOCOCCAL CONJUGATE VACCINATION ON RADIOLOGICAL FINDINGS IN CHEST IN INFANTS HOSPITALIZED WITH COMMUNITY ACQUIRED PNEUMONIA IN NORTHERN INDIA: A CASE-CONTROL STUDY (ID 519)
Abstract
Background
Burden of community acquired pneumonia (CAP) among infants is high in India. Pneumococcal Conjugate Vaccination(PCV) has been introduced in India since 2017 in a phased manner. Our aim was to study the effect of PCV on radiological findings of chest in infants hospitalized with WHO-defined CAP.
Methods
Prospective, hospital-based pneumonia surveillance in four districts of North India. Infants(2-11 months) hospitalized with CAP from index districts with<14 days of symptoms were recruited. Clinical data was abstracted. Chest X-rays(CXRs) were interpreted by a panel of three independent blinded radiologists.
Results
From May,2017-October,2018, 282 (22.7% females) infants with PCV vaccination (cases) and 570 (29.8% females) without PCV vaccination (controls) with interpretable CXRs were analyzed. Primary end point pneumonia (PEP)+other infiltrate (OI) were found in 43(15.2%) cases and 140(24.7%) controls (p=0.001); OI in 30(10.6%) cases and 69(12.1%) controls (p=0.5) and normal CXR in 209(74.1%) cases and 361(63.3%) controls (p=0.001). There was one death among cases whose CXR showed OI. There were 22 deaths among controls whose CXRs showed PEP + OI in 12(54.6%); OI in 3(13.6%) and normal 7(31.8%). Crude odds ratio for death (cases) was 0.088 (95 %: CI 0.012-0.66).
Conclusions
Among hospitalized patients of CAP, radiological findings differ by PCV vaccination status in infants.