10-YEAR PUBLIC HEALTH IMPACT FROM 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PCV13) IN LATIN AMERICA (ID 240)
- Johnna Perdrizet, United States of America
- Johnna Perdrizet, United States of America
- Matt Wasserman, United States of America
- Rodrigo Sini de Almeida, Brazil
Abstract
Background
Pneumococcal conjugate vaccine (PCV) national immunization programs (NIPs) have effectively reduced vaccine serotype pneumococcal disease (PD) morbidity and mortality across Latin America (LatAm). In 2010, the 10-valent and 13-valen PCVs were introduced in routine alimentation. Given PCV13’s broader use and serotype coverage, we quantified its impact across LatAm.
Methods
We calculated the 10-year impact of pediatric PCV13 NIPs in LatAm by estimating PD cases averted and mortality prevented. A model was used to conduct the analysis for ages <5 in 14 LatAm countries that implemented PCV13 NIPs. Data were from reports by the United Nations, World Health Organization, and World Bank for parameters where available. Results are presented by country and aggregately.
Results
Approximately 39.4 million children have been vaccinated. Pediatric PCV13 vaccination translated into 13.7 million total pneumococcal disease cases averted (Table 1). Of the cases averted, 334 thousand were invasive pneumococcal disease, 2.2 million were pneumonia, and 11.2 million were otitis media. Moreover, 49.5 thousand estimated deaths were prevented.
Conclusions
The 10-year history of pediatric PCV13 NIPs in LatAm prevented millions of pneumococcal disease cases and thousands of deaths. However, the true public health impact is underestimated, as herd effects for non-vaccinated groups are not included in the calculations.