Erik -. Backhaus, Sweden
Sahlgrenska University Hospital PediatricsAuthor Of 1 Presentation
INVASIVE PNEUMOCOCCAL DISEASE IN SWEDEN DURING 45 YEARS BEFORE GENERAL INFANT VACCINATION (ID 583)
Abstract
Background
1. Pneumococci cause many deaths world-wide. In the area around Gothenburg in Sweden invasive pneumococcal disease (IPD) has been studied between 1964 and 2009, before any pneumococcal vaccines were used.
Methods
Information about isolations of pneumococci in blood, CSF, synovial, pleural, pericardial and peritoneal fluid was obtained from all bacteriological laboratories in the area.Data were obtained from individual presentation records
Results
1. Totally 4347 patients with IPD were identified. 69 had IPD more than once. The incidence rose continuously from 4.2 to 13.1 cases /100,000 inhabitants/year. The incidence was highest in individuals ≥65 years (45/100,000/year) followed by infants <2 years (23/100,000/year. The most common clinical presentation was sepsis with unknown focus, followed by pneumonia. Meningitis incidence remained unchanged; 1.1 – 1.2 cases/100 000/year. More than 70 % of adult patients had risk factors (high age, alcoholism, malignant or immunological diseases.
Conclusions
1. IPD is a common problem in Sweden mainly affecting the elderly, infants and patients with obvious risk factors.