Arie Van der Ende, Netherlands
Amsterdam University Medical Center Netherlands Reference Laboratory for Bacterial MeningitisAuthor Of 2 Presentations
IMPACT AND EFFECTIVENESS OF THE 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE ON INVASIVE PNEUMOCOCCAL DISEASE IN THE NETHERLANDS (ID 443)
Abstract
Background
In 2011, 10-valent pneumococcal conjugate vaccination (PCV10) was introduced in the Dutch National Immunization Program, after five years of PCV7. We report on the impact and effectiveness of PCV10 in the Netherlands.
Methods
We included IPD cases reported from June 2004 up to May 2019 to our surveillance system. We estimated vaccine effectiveness using the indirect cohort method in children eligible for PCV10. We assessed impact in four age groups by comparing IPD incidences in June 2017-May 2019 and June 2009-May 2011 (before switch to PCV10).
Results
Effectiveness of at least two doses of PCV10 was 90% (63%;97%) against PCV10-type IPD and 29% (-177%;82%) against 19A IPD. Overall IPD incidence decreased by 17% (-5%;35%) in children <5 years, 26% (9%;40%) in 5-49 year-olds, 6% (-10%;19%) in 50-64 year-olds and 2% (-9%;11%) in 65+ year-olds. 19A IPD incidence decreased by 17% (-41%;51%) in children <5 years and by 4% (-103%;55%) in 5-49 year-olds, and increased by 77% (12%;180%) in 50-64 year-olds and by 35% (-1%;84%) in 65+ year-olds.
Conclusions
Despite good effectiveness on vaccine serotypes, the switch to PCV10 has had limited impact on further reducing overall IPD burden after five years of PCV7. Serotype 19A IPD incidence is slowly increasing in older adults.
DYNAMICS OF BACTERIAL CARRIAGE DURING 12 YEARS POST PNEUMOCOCCAL CONJUGATE VACCINE (PCV) INTRODUCTION IN THE NETHERLANDS (ID 871)
Abstract
Background
Control of pneumococcal carriage is key to prevention of pneumococcal disease. We assessed the impact of PCV on carriage prevalence of Streptococcus pneumoniae(Sp) serotypes but also of Haemophilus influenzae(Hi), Staphylococcus aureus(Sa), Moraxella catarrhalis(Mc) and Group A Streptococcus(GAS).
Methods
Cross sectional observational study on carriage prevalence, determined by culture of nasopharyngeal swabs, in 24-month-old children performed in 2018/2019. Data were compared to studies performed in 2009, 2010, 2012 and 2015.
Results
Since PCV7 introduction in 2006 and change to PHiD-CV10 in 2011, overall carriage prevalence has decreased for Sp (66 to 49%) but increased for Hi (52 to 73%), Mc (59 to 83%), Sa (5.6 to 10%) and GAS (2.2 to 6.1%). Pneumococcal PHiD-CV10-type serotypes have disappeared. Initially carriage rate of NVT serotypes 19A, 11A, 10A and 23A increased but has declined again; 6C, 15A, 15B and 23B prevalence is still increasing. In 2018, 6C, 19A, 23B and 15B were the predominant serotypes in carriage and invasive disease in children <5 years of age.
Conclusions
Twelve years post-PCV introduction the decline in pneumococcal carriage has stabilized, but changes in frequency and nature of carried NVT Sp, Hi, Sa, Mc and GAS continued and should be considered for invasive and respiratory infection predictions.