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With reductions in tailpipe emissions of particulate matter, there is an increasing interest in public health impacts of non-tailpipe emissions, specifically tire and brake wear and road dust. Following its well-cited 2010 critical review, a new Health Effects Institute (HEI) expert panel is conducting a systematic review of the epidemiological literature on the health effects of long-term exposure to TRAP, including non-tailpipe emissions. The Panel is using a systematic approach to search the literature, assess study quality, summarize results, and reach conclusions about the body of evidence. They developed a review protocol and registered it in Prospero. An extensive search was conducted of literature published between January 1980 and July 2019. Selected health outcomes include all-cause and cause-specific mortality, respiratory effects, cardiovascular effects, diabetes, and birth outcomes. In addition, the Panel has developed an exposure framework to guide the selection and evaluation of epidemiological studies on TRAP. The review is now well underway, and preliminary results will be presented. After a broad search identifying 1100 studies potentially relevant to the broader review, the panel included 14 studies reporting both relevant health outcomes and epidemiological results for non-tailpipe pollutants. Effect estimates were reported for all-cause mortality (3 papers), circulatory mortality (1 paper), cardiovascular effects (2 papers), respiratory effects (3 papers), and neurodevelopment in children (2 papers). Ten of the papers evaluated effects of copper (Cu) and iron (Fe); others evaluated only Cu (2 papers) or non-exhaust PM_2.5 mass (2 papers). Further evaluation of these papers will inform future research questions related to health effects of non-tailpipe emissions from motor vehicles.