E-POSTER GALLERY (ID 409)

P-0739 - Prenatal Nutrition measured by My Nutrition Index is associated with Birth Weight and Cognitive Function in Children at 7 years

Abstract Control Number
2305
Abstract Body
Nutrition is a multi-faceted, complex construct, where good nutrition should be associated with improved health outcomes. This is particularly true during pregnancy when prenatal maternal nutrition may impact the child’s development. Most research papers on nutrition focus on individual nutrients and health outcomes. In contrast, our focus is on a holistic measure of nutrition. My Nutrition Index (MNI) is an index that measures the nutrient quality (i.e., “nutritiousness”) of a specified daily diet and is calculated based on quantification of dozens of macro- and micronutrients that are specific to an individual’s nutritional needs (as defined by published recommended guidelines for individual nutrient target ranges) by incorporating dietary restrictions, subject characteristics, activity level, and health behaviors. Other nutrition indices are based on scored food groups consumed and may not adequately adjust for micronutrient inadequacies during pregnancy. The Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study is a pregnancy cohort in Värmland, Sweden, with prenatal endocrine disrupting chemicals (EDC) exposure and dietary data available, making it possible to test for the potential mitigating effect of good nutrition on health effects from EDCs. Using prenatal nutrients from food frequency questionnaire (FFQ) data to construct an individual’s MNI, the index is significantly and positively associated with important metabolic (as measured by birth weight) and cognitive function at age 7 years (as measured by IQ-WISC) in children when adjusted for co-variates. Regression models included both prenatal concentrations of an EDC (bisphenol F and PFOA) and MNI demonstrating the adverse association with EDCs and the positive association of a nutritious diet during pregnancy. Thus, MNI is evidently a metric of the general nutritiousness of daily diets and is useful in environmental health studies in representing the impact of good nutrition. (We gratefully acknowledge support from NIEHS: #R01ES028811)