Background. Hundreds of millions of HPV vaccine doses have been administered globally. Post-marketing surveillance studies have confirmed initial observations in clinical trials of a strong safety record. Yet, concerns regarding the safety of the HPV vaccines continue to impede their use. Learning Objectives. The main objective of this session is to understand the status of the safety data for HPV vaccines, and the different sources used to generate these data. Participants will learn to interpret results from safety analyses, and to discern true signals of concern from anecdotes and scare tactics. The specific objectives are to review and understand: 1)Different sources of vaccine adverse event data, and the methodologic approaches used for analyzing the data; 2)Rigorously-collected and interpreted safety data from the USA, Australia and globally; 3)Safety concerns regarding HPV vaccination in Japan; and, 4)Distinguishing true safety concerns from anti-vaccine misinformation and appropriate messaging of vaccine safety data. Presentations and potential speakers. 90 min total Introduction to HPV vaccine monitoring- Suzanne Garland Vaccine safety monitoring in the USA: approaches and resultsLauri Markowitz Vaccine safety monitoring in Australia: approaches and results. Kristine Macartney Vaccine safety monitoring by the WHO: approaches and results. Paul Bloem or WHO representative Scientific evaluation of alleged findings in HPV vaccines in Japan. Ikuo Tsunoda Messaging HPV vaccine safetyAlex Vorsters Discussion. Toshiyuki Sasagawa

Ongoing changes in polices related to prevention of HPV-driven cancers aim to maximize access and effectiveness of these interventions. In the past few years, notable changes have been made to both HPV vaccination and cervical cancer screening policies at the global level. Recent data have also documented the efficacy of anal cancer screening in reducing the incidence of anal cancer in people living with HIV. This session broadly aims to update participants on the rationale, implementation and barriers to the new global policies.