We aim to familiarize our colleagues with the contribution that HPV disease has upon the field of Otolaryngology: specifically with regards to recurrent respiratory papillomas in adults and children. We will be discussing the beneficial effects of HPV vaccination, strategies to increase uptake of the vaccine in high and low resource countries and ways to increase awareness of HPV's relationship to this disorder among providers and patients. We will address the latest developments in terms of adjuvant and surgical treatments and the ongoing clinical trials looking at DNA vaccines at treatment and VLP vaccines for prevention.