Denise A. Galloway, PhD, is the Director of the Pathogen Associated Malignancies Integrated Research Center, and Member of the Human Biology and Public Health Sciences Divisions at the Fred Hutchinson Cancer Research Center. She is also a Research Professor in the Departments of Microbiology and Global Health at the University of Washington. Dr. Galloway’s research has taken a broad-based approach to study the role that small DNA tumor viruses i.e. human papillomaviruses (HPV) and human polyomavirus (HPyV) play in the development of cancers. She has identified mechanisms by which the HPV E6 and E7 oncogenes promote genetic instability, overcoming cell cycle checkpoints and inducing expression of the catalytic subunit of telomerase, hTERT. She has showed that E6/E7 expressing cells are deficient in repairing DNA damage using the Fanconi Anemia/BRCA and homologous recombination pathways, providing new therapeutic targets for HPV associated malignancies. Her lab was among the first to isolate virus-like particles, which became the basis for prophylactic HPV vaccines. In collaboration with epidemiologists, biostatisticians and clinicians her lab helped define the prevalence of HPV, and risk factors associated with the development of cervical and other anogenital and oropharyngeal cancers. Also, in collaborative studies she defined the natural history of HPV infections in young women and men, which was critical in the design of vaccine trials. Her most recent studies have developed new techniques to characterize the long-term memory B cell responses to vaccination. These studies showed that the standard 3 dose schedule was suboptimal, that memory was equivalent comparing two to three doses in adolescents, and that a single dose of vaccine improves the immune response in previously infected women. She has trained over 50 post-doctoral fellows and graduate students. She serves on several editorial boards, grant review committees and National Cancer Institute (NCI) Boards. She is an elected member of the American Academy of Arts and Sciences, the American Academy of Microbiology and the American Association for the Advancement of Science. She is funded by several grants including an NCI Outstanding Investigator Award. She is the recipient of the Paul Stephanus Memorial Endowed Chair and an American Association of Cancer Research Team Science Award for leading an interdisciplinary team working on the role of HPV in anogenital and oropharyngeal cancers.