LAMIA BOUBLENZA (Algeria)
university of Tlemcen biologyPresenter of 2 Presentations
EPIDEMIOLOGICAL PROFILE STUDY OF GENITAL CANCERS IN IN A REGION OF WESTERN ALGERIA BETWEEN 2012 AND 2016 (ID 220)
Abstract
Introduction
A highly probable relationship between several sexually transmitted diseases and the occurrence of genital cancers has been demonstrated by several studies, this has been particularly well documented about cervical cancer and other genital cancers, whose relationship with papillomavirus infections is highly likely. Cervical cancer is the main genital cancer. It represents a real public health problem in Algeria.
Methods
A descriptive retrospective analysis to determine the epidemiological profile of génital cancers over a period of five years between 2012 and 2016 was carried out at epidemiology service of Tlemcen hospital (western Algeria).
Results
A total of 476 cases of genital cancers have been recorded over the last five years, with a peak in 2014 (30%). Cervical cancer was the largest with 233 cases (48.94%). The most represented age group in this study was 51-60 with 31.30%. The average age of genital cancers appearance was 56.5 years, with age extremes ranging from 21 to 92.
Conclusions
Prevention strategies mainly target cervical cancer. The screening program and the vaccine against HPV offer optimism that genital cancers can be prevented.
DETECTION OF HIGH RISK HUMAN PAPILLOMAVIRUS (HR-HPV) IN PRECANCEROUS LESIONS OF CERVICAL CANCER (ID 176)
Abstract
Introduction
The High risk Human Papillomavirus (HR-HPV) is the etiologic agent of cervical cancer, second female cancer in Algeria. The objective of this work is to carry out a preliminary prospective study for the detection of HR-HPV infections in Tlemcen, where screening is based solely on cytology.
Methods
One hundred and thirty (130) cervical specimens were used in this study. HPV detection was performed by the Cobas® 4800 HPV test in a laboratory of medical analysis “Ibn Sina” (Constantine) using a real-time PCR. This test identifies specifically HPV16 and/or HPV18 types, and detects simultaneously the remaining HR-HPV types.
Results
A percentage of 21.5% represents positive HPV specimens (28/130) with 5 multiple infections (HPV16 associated) and 23 single infections. The rate of infection by HPV16 (alone or combined) was 28.6% (8/28). Risk factors that appear to be related to HPV infection were, in addition to HIV infection, the lack of early and regular screening; where the majority of patients performed their smears for the first time at an advanced age whose principal reason of gynecological consultations was hemorrhage on contact. In addition to abusive use of oral contraception, and early age of marriage.
Conclusions
These preliminary results encourage us to develop a study on a larger sample of patients, including the HPV test. This test will optimize the performance of early screening of this cancer in our population; to define the prevalence of HPV infection and the distribution of different genotypes, which is necessary in the introduction of vaccination.