Laia Alemany Vilches (Spain)
Catalan Institute of Oncology - IDIBELL Cancer Epidemiology Research ProgrammePresenter of 2 Presentations
Burden of HPV- associated diseases (ID 45)
AGE PATTERNS IN HPV-POSITIVE AND NEGATIVE ANOGENITAL AND HEAD AND NECK CANCERS (ID 1349)
Abstract
Introduction
Understanding the age patterns of HPV-related and unrelated cancers is important for elucidating natural history of these cancers and guiding cancer prevention interventions.The aim of this re-analyses was to describe the age at diagnosis by the available information of anogenital and head and neck cancers from the RIS HPV TT/VVAP/Head and Neck ICO international surveys.
Methods
Approximately 18,000 formalin-fixed paraffin embedded blocks preserving anogenital and head and neck cancers were included in the analyses. From those patients country, age, gender, histology, anatomicalsite, and HPV results were available. HPV results included: HPV DNA, mRNA and p16INK4a assessment. Age at diagnosis presented missing data. This missingness was approached through a sensitivity analysis technique by implementing a two-step iterative algorithm, in order to model different scenarios of non response under a non ignorable missing pattern assumption. In the case of head and neck and anal cancers the partial observed information was in the outcome of interest (age at diagnosis) and in a binary covariate (gender). For the rest of the cancers present in the anatomical locations cervix, vulva, vagina and penis,the missingness was only present in the age at diagnosis.
Results
Cervical cancer patients were in average 10 years younger at diagnosis than the rest of locations (Table 1). In cancers of the cervix, vulva, and anus, HPV-positive cases where younger than HPV-negative (p<0.05). In cervical cancers, cases with HPVs 16, 18 and 45 where diagnosed at younger ages compared with cases with other types, particularly HPVs 18 and 45 (Table 2). This was not observed in the other anatomical sites.
Conclusions
We have observed different patterns of age at diagnosis by anatomical sites, HPV positivity and HPV types. These differences will help us to understand the natural history of the infection to cancer and may have implications in prevention strategies.