Patti E. Gravitt (United States of America)

University of Maryland School of Medicine Epidemiology and Public Health

Presenter of 2 Presentations

 Conference Calendar
Public Health / Epidemiology / Epidemiology: Natural History/Risk Factors ePoster

RATES OF NEW HPV DETECTION AND LOSS OF DETECTION AMONG MIDDLE-AGED WOMEN IN THE US: ATTRIBUTION TO RECENT ACQUISITION VS NEW DETECTION (ID 955)

Session Date
07/21/2020
Session Time
10:00 - 17:00
Room
ePoster
Session Type
Poster Viewing - 20-24 July
Session Name
Public Health / Epidemiology / Epidemiology: Natural History/Risk Factors
Lecture Time
10:15 - 10:16
Presenter
Authors

Abstract

Introduction

The United States Advisory Committee on Immunization Practices (ACIP) does not recommend routine HPV vaccination for persons over age 26 years but allows vaccination up to age 45 if a benefit to the patient is perceived. Assuming that benefit is gained predominately through prevention of acquisition of new infection (versus reactivation of latent infection), we estimated the fraction of new HPV detections due to new acquisition vs. redetection/reactivation among 731 women aged 35-60 years in Baltimore, MD.

Methods

During 2008-2011, a cervical brush sample was collected for HPV testing by a trained study physician or nurse and participants completed health and sexual behavior questionnaires at baseline and every 6-months over a 2-year period. Rates of new HPV detection were calculated using Kaplan-Meier methods, stratified by recent and past sexual behavior. Population attributable fractions (PAFs) of new HPV detection due to new acquisition vs. redetection were estimated.

Results

Rates of new detection were highest in women reporting a new partner regardless of sexual history, however rates of new detection were over 2-fold higher in women with 5+ lifetime sex partners (LTSP) compared to women with <5 LTSP (Table 1, Figure 1). Of the 67 new HPV detections, 18% occurred in women with <5 LTSP and no new partner, 63% in women with ≥5 LTSP and no new partner, and 19% in women with a new partner. The PAF of new HPV detection due to new acquisition was 17.0% versus 34.3% due to having 5+ LTSP.

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Conclusions

Recent and past sexual behavior independently affects the risk of having a new HPV type detected in this mid-adult population, suggesting that new detection reflects both recent acquisition and recurrent detection of previously acquired infection. These results may be useful in counseling older women undergoing routine HPV-based cervical screening and considering HPV vaccination.

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Oral Session 4: SCREENING II. Evaluation and impact of cervical cancer screening Hall E

DISCRETE EVENT SIMULATION MODELS TO SUPPORT RESOURCE AND OPERATIONAL PLANNING OF CERVICAL CANCER SCREENING PROGRAMS: A PILOT STUDY IN PERU (ID 434)

Session Date
07/22/2020
Session Time
08:45 - 09:45
Room
Hall E
Session Type
Public Health Oral Session
Session Name
Oral Session 4: SCREENING II. Evaluation and impact of cervical cancer screening
Lecture Time
09:33 - 09:45
Presenter
Authors

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Moderator of 1 Session

 Conference Calendar
Public Health Oral Session

01030 - Oral Session 16: EPIDEMIOLOGY II. Burden, natural history and risk factors  (ID 59)

Session Type
Public Health Oral Session
Session Date
07/24/2020
Session Time
12:35 - 13:50
Room
Hall D
Chair(s)

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