D. Delgado (Vitoria-Gasteiz, ES)
Arthroscopy Surgery Unit Advanced Biological Therapy UniPresenter Of 1 Presentation
P214 - Platelet-Rich Plasma for Knee Degenerative Pathology: our Real-world Evidence Experience
Abstract
Purpose
To obtain and analyse the clinical results of Platelet Rich Plasma (PRP) in patients with degenerative knee pathology derived from real-world data.
Methods and Materials
Two prospective studies were designed to analyse collected real-world data. One enrolled 1139 patients and evaluated clinical outcomes at 6 and 15 months after the treatment, using the Knee injury and Osteoarthritis Outcome Score and obtaining percentages of Minimal Clinically Important Improvement (MCII). The other study enrolled 753 patients and analysed the delay of total knee arthroplasty (TKA) in patients treated with PRP through a 5-year survival study. Both approaches evaluated several factors that could influence the efficacy of PRP, namely age, body mass index (BMI), severity, PRP cycles and administration route. PRP quality controls were conducted to ensure that the PRP met the stated properties.
Results
In the clinical outcome study, 531 cases were finally included in the analysis and the percentage with MCII at 6 and 15 months after PRP was 59.32% and 70.62%, respectively. MCII patients were younger (P=0.024) and with lower BMI (P=0.045). Mild/moderate cases had a better response (P<0.001). Intraosseous PRP in severe cases improved the effect of intraarticular PRP (P=0.035). Second cycles of PRP improved the response in mild/moderate cases without MCII at 6 months (P=0.035). In the survival study, 273 cases were analysed and 85.71% of cases did not undergo TKA. Age (p<0.001), severity (p=0.001), number of cycles (P=0.005) and administration route (P=0.005) had a statistically significant influence on the efficacy of PRP in delaying surgery. PRP had a platelet concentration 1.76 ± 0.38 fold higher than blood without leukocytes and erythrocytes.
Conclusion
PRP showed to be effective in degenerative knee pathology and it depends on factors related to the patient, the pathology, the product and the protocol. Data from real-world evidence studies can complement data from clinical trials to provide valuable information.
Presenter Of 1 Presentation
P214 - Platelet-Rich Plasma for Knee Degenerative Pathology: our Real-world Evidence Experience
Abstract
Purpose
To obtain and analyse the clinical results of Platelet Rich Plasma (PRP) in patients with degenerative knee pathology derived from real-world data.
Methods and Materials
Two prospective studies were designed to analyse collected real-world data. One enrolled 1139 patients and evaluated clinical outcomes at 6 and 15 months after the treatment, using the Knee injury and Osteoarthritis Outcome Score and obtaining percentages of Minimal Clinically Important Improvement (MCII). The other study enrolled 753 patients and analysed the delay of total knee arthroplasty (TKA) in patients treated with PRP through a 5-year survival study. Both approaches evaluated several factors that could influence the efficacy of PRP, namely age, body mass index (BMI), severity, PRP cycles and administration route. PRP quality controls were conducted to ensure that the PRP met the stated properties.
Results
In the clinical outcome study, 531 cases were finally included in the analysis and the percentage with MCII at 6 and 15 months after PRP was 59.32% and 70.62%, respectively. MCII patients were younger (P=0.024) and with lower BMI (P=0.045). Mild/moderate cases had a better response (P<0.001). Intraosseous PRP in severe cases improved the effect of intraarticular PRP (P=0.035). Second cycles of PRP improved the response in mild/moderate cases without MCII at 6 months (P=0.035). In the survival study, 273 cases were analysed and 85.71% of cases did not undergo TKA. Age (p<0.001), severity (p=0.001), number of cycles (P=0.005) and administration route (P=0.005) had a statistically significant influence on the efficacy of PRP in delaying surgery. PRP had a platelet concentration 1.76 ± 0.38 fold higher than blood without leukocytes and erythrocytes.
Conclusion
PRP showed to be effective in degenerative knee pathology and it depends on factors related to the patient, the pathology, the product and the protocol. Data from real-world evidence studies can complement data from clinical trials to provide valuable information.