S. Sezaki (ayabe, JP)
GUNZE LIMITED QOL Research Center LaboratoryPresenter Of 1 Presentation
P047 - Evaluation of Mechanical and Biomechanical Properties of Novel Meniscal Scaffold Using Bioabsorbable Materials
Abstract
Purpose
We have been developing a novel meniscal scaffold (PGA scaffold), which is consist of polyglycolic acid (PGA) covered with L-lactide-ε-caprolactone copolymer (P(LA/CL)). Meniscus acts as load distribution in the knee and the biomechanical properties are essential for the development of PGA scaffold. The purpose of this study was to evaluate the mechanical evaluation of the PGA scaffold and the biomechanical properties after PGA scaffold implantation using porcine knees.
Methods and Materials
Mechanical properties of PGA scaffolds were tested in a cyclic relaxation test from 0 to 7 N and were evaluated the stiffness of at time 0, 2 and 4 weeks of hydrolysis. The pressure sensor was used a pressure-sensitive conductive rubber sensor that is easy to mold, flexible, and resistant to shearing force. Contact pressure of meniscus was obtained from the pressure sensor using the medial meniscus and femur of the porcine knee. Three conditions of intact, meniscectomy, and scaffold implantation were prepared, and 100 N of compressive load was applied and contact pressure and area were calculated on lubber sensor, respectively.
Results
PGA scaffolds had the same strength as the initial stage up to 2 weeks of hydrolysis, and the strength of 4 weeks of hydrolysis was 72.3% of the initial strength (Fig. 1). The contact pressure was significantly higher, whereas the contact area was significantly smaller in the meniscectomy than in the intact (P < 0.05), however, the scaffold implantation recovered to the same contact pressure and contact area as well as the intact menisci (Fig. 2).
Conclusion
PGA scaffolds had an initial strength of 70% or more up to 4 weeks after surgery and indicating that the PGA scaffolds had been potential as the option of meniscus treatment in terms of improving mechanical properties after injury.
Presenter Of 1 Presentation
P047 - Evaluation of Mechanical and Biomechanical Properties of Novel Meniscal Scaffold Using Bioabsorbable Materials
Abstract
Purpose
We have been developing a novel meniscal scaffold (PGA scaffold), which is consist of polyglycolic acid (PGA) covered with L-lactide-ε-caprolactone copolymer (P(LA/CL)). Meniscus acts as load distribution in the knee and the biomechanical properties are essential for the development of PGA scaffold. The purpose of this study was to evaluate the mechanical evaluation of the PGA scaffold and the biomechanical properties after PGA scaffold implantation using porcine knees.
Methods and Materials
Mechanical properties of PGA scaffolds were tested in a cyclic relaxation test from 0 to 7 N and were evaluated the stiffness of at time 0, 2 and 4 weeks of hydrolysis. The pressure sensor was used a pressure-sensitive conductive rubber sensor that is easy to mold, flexible, and resistant to shearing force. Contact pressure of meniscus was obtained from the pressure sensor using the medial meniscus and femur of the porcine knee. Three conditions of intact, meniscectomy, and scaffold implantation were prepared, and 100 N of compressive load was applied and contact pressure and area were calculated on lubber sensor, respectively.
Results
PGA scaffolds had the same strength as the initial stage up to 2 weeks of hydrolysis, and the strength of 4 weeks of hydrolysis was 72.3% of the initial strength (Fig. 1). The contact pressure was significantly higher, whereas the contact area was significantly smaller in the meniscectomy than in the intact (P < 0.05), however, the scaffold implantation recovered to the same contact pressure and contact area as well as the intact menisci (Fig. 2).
Conclusion
PGA scaffolds had an initial strength of 70% or more up to 4 weeks after surgery and indicating that the PGA scaffolds had been potential as the option of meniscus treatment in terms of improving mechanical properties after injury.