N. Mirnik (Ankaran, SI)
Valdoltra Orthopaedic HospitalPresenter Of 1 Presentation
P130 - Comparison of Outcomes of Treating Knee Arthrosis with Cultured Adipose Stem Cells or Hyaluronic Acid
Abstract
Purpose
The aim of our study was to compare the effectiveness of treating symptoms of knee arthrosis with cultured adipose stem cell (ADSC) infiltration, and compare them with hyaluronic acid (HA) infiltration. We wanted to check if there is a potential of cartillage regrowth after ADSC infiltration.
Methods and Materials
10 patients with knee arthrosis ICRS grade 3-4 were included in each group and were followed prospectively after the infiltration for 12 months with the VAS scale and the KOOS questionnaire that consists of 5 subscales; Pain, other Symptoms, Function in daily living (ADL), Function in sport and recreation (Sport/Rec) and knee related Quality of life (QOL). From KOOS a KOOS4 score and WOMAC score were calculated. MRI of the knee was performed before and a year after the infiltration. In ADSC group 6 ml of 10 x 106 ADSC, in HA group 6 ml with 60 mg of HA was infiltrated in the knee.
Results
VAS at baseline, at one week, 3 months, 6 months and 1 year was 6.9 (SD 0.9), 3.6 (SD 2.0), 3.1 (SD 3.6), 4 (SD 2.9) and 3.4 (SD 3.7) in ADSC group and 4.6 (SD 2.2), 4.1 (SD 1.8), 4.2 (SD 2.0), 4 (SD 2.3), 4.9 (SD 2.0) in HA group. KOOS4 at baseline, at one week, 3 months, 6 months and 1 year was 33.1 (SD 16.5), 51.9 (SD 12.8), 61 (SD 22.7), 52.9 (SD 21.9), 54.2 (SD 29.7) in ADSC group and 42 (SD 15.5), 42.8 (SD 16.4), 49.6 (SD 16.6), 52 (SD 21.3), 47.6 (SD 16.4) in HA group. MRI has shown cartillage regrowth in a year followup in the ADSC group.
Conclusion
HA and ADSC are effective for treating symptoms of arthrosis but ADSC are much more effective and provide an effect even a year after infiltration. Effect on cartillage regrowth with ADSC is possible.
Presenter Of 1 Presentation
P130 - Comparison of Outcomes of Treating Knee Arthrosis with Cultured Adipose Stem Cells or Hyaluronic Acid
Abstract
Purpose
The aim of our study was to compare the effectiveness of treating symptoms of knee arthrosis with cultured adipose stem cell (ADSC) infiltration, and compare them with hyaluronic acid (HA) infiltration. We wanted to check if there is a potential of cartillage regrowth after ADSC infiltration.
Methods and Materials
10 patients with knee arthrosis ICRS grade 3-4 were included in each group and were followed prospectively after the infiltration for 12 months with the VAS scale and the KOOS questionnaire that consists of 5 subscales; Pain, other Symptoms, Function in daily living (ADL), Function in sport and recreation (Sport/Rec) and knee related Quality of life (QOL). From KOOS a KOOS4 score and WOMAC score were calculated. MRI of the knee was performed before and a year after the infiltration. In ADSC group 6 ml of 10 x 106 ADSC, in HA group 6 ml with 60 mg of HA was infiltrated in the knee.
Results
VAS at baseline, at one week, 3 months, 6 months and 1 year was 6.9 (SD 0.9), 3.6 (SD 2.0), 3.1 (SD 3.6), 4 (SD 2.9) and 3.4 (SD 3.7) in ADSC group and 4.6 (SD 2.2), 4.1 (SD 1.8), 4.2 (SD 2.0), 4 (SD 2.3), 4.9 (SD 2.0) in HA group. KOOS4 at baseline, at one week, 3 months, 6 months and 1 year was 33.1 (SD 16.5), 51.9 (SD 12.8), 61 (SD 22.7), 52.9 (SD 21.9), 54.2 (SD 29.7) in ADSC group and 42 (SD 15.5), 42.8 (SD 16.4), 49.6 (SD 16.6), 52 (SD 21.3), 47.6 (SD 16.4) in HA group. MRI has shown cartillage regrowth in a year followup in the ADSC group.
Conclusion
HA and ADSC are effective for treating symptoms of arthrosis but ADSC are much more effective and provide an effect even a year after infiltration. Effect on cartillage regrowth with ADSC is possible.