Cervical cancer is a serious health problem, with nearly 500,000 women developing the disease each year worldwide. Most early-stage tumors women are curable. After careful clinical evaluation and staging, the primary treatment of early-stage cervical cancer is either surgery or radiotherapy or combined and there is a lack of preoperative radiotherapy trials alone so we aim to assess its impact on survival in early stage versus postoperative radio and surgery.
Objective
to evaluate the survival rate of pre versus postoperative radiotherapy compared to radical hysterectomy without systemic treatment in early stage (I, IIA2) cervical cancer patients.
We conducted a study using population-based data. Data was extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database. Diagnosed women with early stage cervical cancer (I,IIA2) from 2010 to 2015 and received treatment into three groups preoperative, surgery only and postoperative radiotherapy. We calculated the survival rate.
Out of 4399 female patients, 3988 were treated with radical hysterectomy without systemic therapy while 493 had postoperative radiation and 7 had preoperative radiation. The 5 year overall survival for postoperative radiation is better than preoperative radiation (85.8%,71.4% respectively) while radical hysterectomy without systemic treatment has 5 year survival of 93.2%,P> 0.00) .pre-operative radiation shows the worst survival outcome in the age groups 20-45 years and 46-70 years(80%,50%).
The results obtained in this study demonstrated that radical hysterectomy has survival benefit of 8 % than postoperative radiotherapy. Preoperative radiotherapy alone needs more studies to evaluate its impact on survival rate and patients have to be evaluated individually.