Author Of 1 Presentation
A NOVEL SELF-SHIELDED X-RAY IRRADIATION SYSTEM FOR LABORATORY FLASH RADIATION RESEARCH
Abstract
Background and Aims
Pre-clinical laboratory research to elucidate biological effects of FLASH irradiation is imperative to support its clinical translation. At present, FLASH research employs complex accelerator technologies of limited accessibilities. Here, we introduce a novel self-shielded FLASH x-ray cabinet system to support preclinical research.
Methods
The proposed system employs two commercially available high-capacity 150 kVp x-ray sources with rotating anode technology in a parallel-opposed arrangement. X-ray sources are supported by independent bidirectional computer-controlled vertical and rotational motions for conformal and angled irradiation (Figure 1). A radiochromic film validated Monte-Carlo simulation platform (Geant4) was used to characterize the dosimetry of the system.
Results
This system delivers doses up to 67 Gy to a 20-mm thick water equivalent medium at both FLASH and conventional dose-rates of 40-240 Gy/s and <0.1 Gy/s, respectively. Depth dose-rate uniformity (±5%) is achieved over 8-12 mm in the central region of the medium. The mirrored beams minimize heel effect of the source and achieve cross-beam uniformity within ±3%. Field dimension is adjustable, ranging from 0.1–5.5 cm and 0.1–20 cm for FLASH and conventional irradiation, respectively, suitable for small animal and cell culture irradiations. Angling the two beams minimizes entrance and exit beams overlap, and reduces surface doses up to 39%.
Conclusions
This system greatly enhances FLASH radiation research in regular laboratory setting. In-vivo studies are being conducted to demonstrate kVp x-rays induced FLASH effects on superficial murine models. Results will be presented.