Presenter of 1 Presentation
A FEASIBILITY STUDY OF IORT-FLASH USING A GPU-BASED FAST MONTE CARLO
Abstract
Background and Aims
Intra Operative Radiation Therapy (IORT) may represent one of the first clinical modalities of a Flash clinical treatment. Within IORT, whenever needed and possible, temporarily beam modifiers (such as the protection disc for breast carcinoma treatment) are used to protect the underlying healthy tissues during the irradiation. In this contribution we investigate the efficiency achievable in IORT-FLASH treatment using a GPU-based fast Monte Carlo called FRED (Fast particle thErapy Dose evaluator), as a tool for dose calculation and treatment optimization.
Methods
The FRED MC has been developed to allow a fast optimization of the Treatment Planning System in Particle Therapy (simulation time reduced by a factor of 1000), while keeping the dose release accuracy typical of a MC tool. We have simulated in detail the geometry and the material of the applicator coupled with the linac, provided by the SIT company (Aprilia, Italy). We have then combined the FRED simulation with a simple modelling of the FLASH effect and compared it with a conventional IORT treatment.
Results
The tumour coverage and the dose absorbed by the organs at risk have been compared, carrying out a quantitative analysis comparing the obtained Dose Volume Histograms, with a standard IORT treatment.
Conclusions
The results demonstrate the potential of FLASH effect in IORT and of FRED as a tool for treatment planning and dose-report calculations.
Author Of 1 Presentation
A FEASIBILITY STUDY OF IORT-FLASH USING A GPU-BASED FAST MONTE CARLO
Abstract
Background and Aims
Intra Operative Radiation Therapy (IORT) may represent one of the first clinical modalities of a Flash clinical treatment. Within IORT, whenever needed and possible, temporarily beam modifiers (such as the protection disc for breast carcinoma treatment) are used to protect the underlying healthy tissues during the irradiation. In this contribution we investigate the efficiency achievable in IORT-FLASH treatment using a GPU-based fast Monte Carlo called FRED (Fast particle thErapy Dose evaluator), as a tool for dose calculation and treatment optimization.
Methods
The FRED MC has been developed to allow a fast optimization of the Treatment Planning System in Particle Therapy (simulation time reduced by a factor of 1000), while keeping the dose release accuracy typical of a MC tool. We have simulated in detail the geometry and the material of the applicator coupled with the linac, provided by the SIT company (Aprilia, Italy). We have then combined the FRED simulation with a simple modelling of the FLASH effect and compared it with a conventional IORT treatment.
Results
The tumour coverage and the dose absorbed by the organs at risk have been compared, carrying out a quantitative analysis comparing the obtained Dose Volume Histograms, with a standard IORT treatment.
Conclusions
The results demonstrate the potential of FLASH effect in IORT and of FRED as a tool for treatment planning and dose-report calculations.