Presenter of 1 Presentation
LASER-DRIVEN PROTON SOURCE FOR IN-VITRO AND IN-VIVO HIGH DOSE, ULTRA-HIGH DOSE-RATE EXPERIMENTS
Abstract
Background and Aims
Laser-driven proton acceleration produces short radiation bunches with a continuous energy spectrum up to a sharp cutoff; in previous experiments our group proved the biological effect of a “laser-driven fast-fractionation” modality, where the target dose is deposited by a number of ultra-short radiation pulses at ultra-high instantaneous dose-rate. In a new experiment we aim at reaching the relevant target dose in a single laser pulse (which would be a million times shorter that the accepted limit for FLASH effect) and using multiple spectral components to produce an SOBP for thicker biological samples.
Methods
We used the pico2000/LULI laser facility for proton acceleration, using 12.5um gold targets. The particle transport was ensured by a remotely-controlled beam-line composed by two permanent-magnet quadrupoles (LMU) and a scattering system. Dosimetry measurements were performed with radiochromic films, previously calibrated on the CPO/Institut Curie medical accelerator.
Results
A total charge exceeding 150nC/shot was measured, in a continuous spectrum up to 16MeV. At the biological sample plane a maximum deposited dose of 20Gy/shot could be obtained on a surface of 1cm2 and within an estimated deposition time of 10ns. Dose escalation at the irradiation plane, ensured by variable quadrupole configurations, was applied on monolayer cell cultures and on zebrafish embryos. A precise modelling of the dosimetric data is currently being realised.
Conclusions
A high-energy-laser-driven proton irradiation line capable of producing FLASH-like conditions on a mm thick sample in a sub-us time was demonstrated. Fixed, post-development embryos and cell survival assays are currently under analysis.
Author Of 1 Presentation
LASER-DRIVEN PROTON SOURCE FOR IN-VITRO AND IN-VIVO HIGH DOSE, ULTRA-HIGH DOSE-RATE EXPERIMENTS
Abstract
Background and Aims
Laser-driven proton acceleration produces short radiation bunches with a continuous energy spectrum up to a sharp cutoff; in previous experiments our group proved the biological effect of a “laser-driven fast-fractionation” modality, where the target dose is deposited by a number of ultra-short radiation pulses at ultra-high instantaneous dose-rate. In a new experiment we aim at reaching the relevant target dose in a single laser pulse (which would be a million times shorter that the accepted limit for FLASH effect) and using multiple spectral components to produce an SOBP for thicker biological samples.
Methods
We used the pico2000/LULI laser facility for proton acceleration, using 12.5um gold targets. The particle transport was ensured by a remotely-controlled beam-line composed by two permanent-magnet quadrupoles (LMU) and a scattering system. Dosimetry measurements were performed with radiochromic films, previously calibrated on the CPO/Institut Curie medical accelerator.
Results
A total charge exceeding 150nC/shot was measured, in a continuous spectrum up to 16MeV. At the biological sample plane a maximum deposited dose of 20Gy/shot could be obtained on a surface of 1cm2 and within an estimated deposition time of 10ns. Dose escalation at the irradiation plane, ensured by variable quadrupole configurations, was applied on monolayer cell cultures and on zebrafish embryos. A precise modelling of the dosimetric data is currently being realised.
Conclusions
A high-energy-laser-driven proton irradiation line capable of producing FLASH-like conditions on a mm thick sample in a sub-us time was demonstrated. Fixed, post-development embryos and cell survival assays are currently under analysis.