Sascha Verbruggen (Netherlands)

Erasmus Medical Centre-Sophia Children's Hospital Paediatric Intensive Care Unit
Dr. Sascha Verbruggen works as attending staff in the Department of Pediatric Intensive Care, ErasmusMC - Sophia Children’s Hospital, Rotterdam, The Netherlands. He is a clinician-scientist focusing on nutrition and metabolism in critical illness, with a special interest on the long-term consequences for critically ill children. In 2007-2008 Dr Verbruggen worked as research fellow in nutrition and metabolism at the Children Nutrition Research Center (CNRC), and the PICU of the Texas Children’s Hospital, Houston, Texas, USA. After his return to Rotterdam, he began his pediatric clinical work in the Pediatric ICU of the Erasmus MC–Sophia children’s hospital, while continuing his research in the field of nutrition & metabolism in critically ill children. This led to his PhD “Protein, Energy, and their Interaction in Critically Ill Children” in December 2010. Together with Prof. Dr. KFM Joosten, he has established a nutrition and metabolic research unit, with ongoing research regarding nutrition and metabolism in critically ill children at the Erasmus MC–Sophia Children’s Hospital. Since 2018 he is the chair of the Metabolism and Nutrition section of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC)

Author Of 4 Presentations

09:30 AM - 09:32 AM

CHAIRPERSON INTRODUCTION

Lecture Time
09:30 AM - 09:32 AM
08:50 AM - 09:10 AM

FEEDING THE OBESE CHILD IN THE PICU

Lecture Time
08:50 AM - 09:10 AM
12:11 PM - 12:21 PM

HYPOPHOSPHATAEMIA IS ASSOCIATED WITH WORSE CLINICAL OUTCOME IN CRITICALLY ILL CHILDREN – A SECONDARY ANALYSIS OF THE PEPANIC RCT

Lecture Time
12:11 PM - 12:21 PM

Abstract

Background and Aims

Withholding parenteral nutrition (PN) during the first week in PICU (late-PN vs. early-PN) accelerated recovery and reduced new infections. Hypophosphataemia may occur when enteral or parenteral nutrition is reintroduced. We investigated whether hypophosphataemia was associated with clinical outcomes affected by PN.

Methods

For this secondary analysis of the PEPaNIC-RCT (N=1440) patients with renal replacement therapy were excluded. Hypophosphataemia was defined as serum phosphate <0.65 mmol/L on any of the studied days (day 1-14 of PICU admission). Multivariable Cox proportional hazard and logistic regression analyses assessed the association of hypophosphataemia with likelihood of early live weaning from mechanical ventilation and PICU discharge, and risk of new infection, adjusted for baseline risk factors and randomisation.

Results

1247 patients were eligible (618 early-PN, 629 late-PN). Median age was 1.6 years (IQR 0.3-6.7); 705 (56.5%) were male and median PELOD was 21 (IQR 12-31). Hypophosphataemia occurred in 109 patients (76 early-PN, 33 late-PN; p<0.001). Hypophosphataemia was associated with lower likelihood of early live weaning from mechanical ventilation (HR, 0.62; p<0.001), lower likelihood of early live discharge from PICU (HR, 0.54; p<0.001) and more new infections (OR, 4.06; p<0.001) (Table 1).

table 1.png

Conclusions

The occurrence of hypophosphataemia was independently associated with a lower likelihood of early live weaning from mechanical ventilation, a lower likelihood of early live discharge from PICU and with more new infections.

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11:31 AM - 11:47 AM

PROTEIN INTAKE IN CRITICAL ILLNESS – THE CASE FOR LOW/NORMAL INTAKE

Lecture Time
11:31 AM - 11:47 AM

Presenter of 3 Presentations

11:31 AM - 11:47 AM

PROTEIN INTAKE IN CRITICAL ILLNESS – THE CASE FOR LOW/NORMAL INTAKE

Lecture Time
11:31 AM - 11:47 AM
08:50 AM - 09:10 AM

FEEDING THE OBESE CHILD IN THE PICU

Lecture Time
08:50 AM - 09:10 AM
09:30 AM - 09:32 AM

CHAIRPERSON INTRODUCTION

Lecture Time
09:30 AM - 09:32 AM

Moderator of 1 Session

Session Time
09:30 AM - 11:00 AM
Room
Hall D
Session Type
Xchange
Date
06/16/2021