Author Of 1 Presentation
MYOCARDIAL STRAIN IN VASCULAR ANOMALIES WITH SEVERE UPPER AIRWAY OBSTRUCTION: PRELIMINARY RESULTS
- Anna Claudia Massolo, Italy
- Francesco Morini, United States of America
- Ferdinando Savignoni, United States of America
- Francesca Monaco, United States of America
- Paola Giliberti, United States of America
- Marco Campanale, United States of America
- Alessandra Toscano, United States of America
- Pietro Bagolan, United States of America
- Andrea Dotta, United States of America
- Annabella Braguglia, United States of America
Abstract
Background
Vascular anomalies (VA) may cause in some cases severe tracheomalacia. Chronic upper airway obstruction (UAO) is the most common symptom. Increased pulmonary pressure and cardiac dysfunction have been described in patients with chronic UAO, but not in infants with VA-associated UAO.
Objectives
To evaluate myocardial strain in infants with VA-associated UAO.
Methods
Demographic characteristics, respiratory symptoms and the percentage of tracheal obstruction measured on CT were collected. Left and right ventricle (LV, RV) systolic function were measured with speckle tracking longitudinal strain analysis (LS). Pulmonary artery pressure (PAP) was evaluated on tricuspid regurgitation jet (TR) and quantified by end-systolic eccentricity index (EI).
Results
15 cases were included, of which six had a tracheal occlusion <50%, and nine >50%. Cases with tracheal occlusion >50% had significantly more pronounced respiratory symptoms and LV and RV function were significantly reduced compared to those with occlusion <50% (LV -15.9% vs -19.9%; RV -15.7% vs -20.5%, respectively). Degree of UAO did not seem to have a significant impact on PAP.
Conclusion
In cases with VA with severe tracheomalacia RV and LV myocardial strain are reduced, suggesting myocardial impairment. Future studies with larger sample size are needed to confirm these data and investigate cardiac function. Association with lung function test may be investigated too.