Author Of 1 Presentation
THE IMPACT OF PROPOFOL ON MYOCARDIAL FUNCTION IN NEONATES IS FORMULATION DEPENDENT
- Anna Claudia Massolo, Italy
- Neil Patel, United States of America
- Stefania Sgrò, United States of America
- Fiammetta Piersigilli, United States of America
- Karel Allegaert, United States of America
- Irma Capolupo, United States of America
- Jole Rechichi, United States of America
- Alessandra Toscano, United States of America
- Andrea Dotta, United States of America
Abstract
Background
Propofol is a useful anesthetic for short invasive procedures with a rapid onset and fast recovery time. Some studies described hypotension in neonates but the mechanisms underlying it are not fully understood.
Objectives
To evaluate the effects of propofol in diluted and undiluted formulation on cardiac function in infants.
Methods
Infants receiving propofol sedation for central line insertion were included. Cases were divided in two groups, those who received undiluted propofol at 1% (P1%) and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were collected pre (t0) and immediately post propofol (t1) administration and additionally 1 hour post propofol (t2). For both left ventricle (LV) and right ventricle (RV), myocardial deformation was assessed with tissue Doppler analysis (TDI) and peak longitudinal strain (LS) to evaluate systolic and diastolic function. Systolic and diastolic pressure were collected at t1.
Results
18 cases were included, of which nine received 1% propofol, and nine received diluted propofol. Adequate procedural sedation was achieved in both groups. In the P1% group, TDI and LS for both RV and LV function were significantly reduced at t1and t2. In the Pd Group, only TDI LV was reduced at t1, but not at t2. Three infants in the P1% Group and none in the Pd group had clinically significant hypotension at t1.
Conclusion
Dilution of propofol may minimize myocardial dysfunction whilst maintaining adequate sedation in infants. Further studies are needed to investigate the comparative safety and efficacy of this approach.