Author Of 1 Presentation
SERUM COPEPTIN CONCENTRATION AND BIRTH WEIGHT LOSS IN PRETERM NEWBORNS IN THE FIRST DAYS OF LIFE
Abstract
Background
Post-delivery birth weight loss (PDBWL) is a natural process with poorly defined predictors in premature population. Copeptin (CTproAVP), released in stoichiometric amount equal to vasopressin, is regarded as a promising, stabile marker of fluid volume, potentially applicable in the monitoring of fluid therapy.
Objectives
Hypothetically PDBWL is expected to correlate with CTproAVP in the first week of life and may help in decision making regarding fluid therapy.
Methods
155 preterm newborns 30+0-36+6 GA were enrolled and observed up to the 7th day of life(DOL). CTproAVP measurement was performed up to the 2nd and between 4th-7thDOL. The results were compared with body weight and PDBWL, laboratory measurements, and selected maternal and neonatal clinical data.
Results
Mean PDBWLmax was 9.3 ± 1.8% (4.9 ± 3.6 and 4.4 ± 5.1% in first and second measurements, respectively). Median CTproAVP was 157 (1-3Q: 104-273) and 173 (115-277) pmol/ml. There was no correlation between CTproAVP and PDBWL, except the 1’CTproAVP value and the 2’PDBWL (R=0.165, p<0.05). Similar CTproAVP concentrations were found regardless of distinguished PDBWL ranges (<8, 8.0-9.9 and ≥10%). CTproAVP values were not affected by selected demographic and clinical data, except: 1’ and 5’Apgar evaluations, haematocrit and fluid administration up to 2nd DOL.
Conclusion
Serum CTproAVP concentration does not predict post-delivery birth weight loss in clinically stable preterm newborns treated according to routine medical management. This observation may be restricted to limited ranges of hydration disturbances, without significant pathology.