Author Of 1 Presentation
DOES THE AGE MATTER?
Abstract
Background
The hemostasis system in neonates and infants is characterized by functional immaturity due to age-specific differences in proteins.
Objectives
The aim of this study was to identify clinical significance age specificity in pediatric coagulation profile.
Methods
We assessed the coagulation tests (aPPT, PT, fibrinogen level, INR) in 850 patients admitted into PICU. All patients received heparin therapy to prevent thromboembolic events (UFH) infusion consisting of the washing solution (3 IU/ml). 8 pts with v-a ECMO were excluded. We compared 3 age groups: neonates, n=132; infants, n=367; and children, n=343. We assessed the row data and during preventive heparin therapy ones. For statistics we used nonparametric computations
Results
We found that PT 11.83±1.118, 11.75±1.302, and 12.25±1.071, respectively. PT in infants was significantly less than in children group, p<0.05. We not found any differences in aPPT between age groups; aPPT was 35.37±5.55, 34.15±5.51, and 34.99±5.52, respectively, p>0.05. INR before preventive heparin therapy among infants was significantly high than in children, p<0.05. And, than we compared fibrinogen levels in these groups, we’ve found that infants have significantly low fibrinogen levels than patients in children group. The lowest fibrinogen was in neonate group. Fibrinogen (m ±SD) was 2.58±0.45, 2.66±0.74, and 2.92±0.62, respectively. Fibrinogen level in infants was significantly less than in children group, p<0.05.The preventive therapy was effective and there were not any thromboembolic events during treatment.
Conclusion
The hemostasis system in children has dynamic development and before any preventive or treatment intervention we should assess initial coagulation profile with regard to age-dependent specificity.
Presenter of 1 Presentation
DOES THE AGE MATTER?
Abstract
Background
The hemostasis system in neonates and infants is characterized by functional immaturity due to age-specific differences in proteins.
Objectives
The aim of this study was to identify clinical significance age specificity in pediatric coagulation profile.
Methods
We assessed the coagulation tests (aPPT, PT, fibrinogen level, INR) in 850 patients admitted into PICU. All patients received heparin therapy to prevent thromboembolic events (UFH) infusion consisting of the washing solution (3 IU/ml). 8 pts with v-a ECMO were excluded. We compared 3 age groups: neonates, n=132; infants, n=367; and children, n=343. We assessed the row data and during preventive heparin therapy ones. For statistics we used nonparametric computations
Results
We found that PT 11.83±1.118, 11.75±1.302, and 12.25±1.071, respectively. PT in infants was significantly less than in children group, p<0.05. We not found any differences in aPPT between age groups; aPPT was 35.37±5.55, 34.15±5.51, and 34.99±5.52, respectively, p>0.05. INR before preventive heparin therapy among infants was significantly high than in children, p<0.05. And, than we compared fibrinogen levels in these groups, we’ve found that infants have significantly low fibrinogen levels than patients in children group. The lowest fibrinogen was in neonate group. Fibrinogen (m ±SD) was 2.58±0.45, 2.66±0.74, and 2.92±0.62, respectively. Fibrinogen level in infants was significantly less than in children group, p<0.05.The preventive therapy was effective and there were not any thromboembolic events during treatment.
Conclusion
The hemostasis system in children has dynamic development and before any preventive or treatment intervention we should assess initial coagulation profile with regard to age-dependent specificity.