Author Of 1 Presentation
HEALTH-RELATED QUALITY OF LIFE OF CHILDREN AND THEIR PARENTS TWO YEARS AFTER CRITICAL ILLNESS; THE ROLE OF PARENTERAL NUTRITION
Abstract
Background
The Pediatric Early versus Late Parenteral Nutrition in Critical Illness (PEPaNIC) multicenter, randomized controlled trial (RCT) showed that withholding supplemental parenteral nutrition (PN) for up to one week in the pediatric intensive care unit (PICU) resulted in better outcomes [1,2] compared with initiating parenteral nutrition early on day one of admission to the PICU.
Objectives
This study investigates, two years after the PEPaNIC RCT, parent-reported Health-Related Quality of Life (HRQoL) of critically ill children compared with that of a healthy control group. Furthermore, effects of late-PN compared with early-PN during the first week in the PICU on long-term parent-reported HRQoL were examined. Parents’ own HRQoL was examined and was associated with the HRQoL they reported regarding their child.
Methods
All survivors of the 1440 children who participated in the RCT were approached for this 2-years follow-up. Patients were compared with 405 matched healthy children. Assessed outcomes comprised parent-reported HRQoL of the child and the parent. Measurements consisted of the parent-reported Infant Toddler Quality of Life Questionnaire (ITQOL, 0-3 years old), the parent-reported Child Health Questionnaire-Parent Form 50 (CHQ-PF50, 4-18 years old), and the parent-reported Health Utilities Index (HUI). For parents’ own HRQoL the self-reported Short Form Health Survey (SF-12) was used. To adjust for missing data, multiple data imputation by chained equations will be performed prior to univariable and multivariable linear and logistic regression analyses adjusted for risk factors.
Results
Analyses are planned at the end of January.
Conclusion
Conslusions will be presented at the conference.